Remeron

Generic Name: Mirtazapine

  • What is Remeron?

    Remeron is used to treat a certain type of depression called major depressive disorder.

  • What is the most important information I should know about Remeron?

    Antidepressant medicines, including Remeron, may increase suicidal thoughts or actions in some children, teenagers, and young adults when the medicine is first started. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. People with bipolar disorder or who have a family history of this condition (also called manic-depressive illness) are at a greater risk. Contact your doctor immediately if you experience any changes, especially sudden ones, in mood, behavior, thoughts, or feelings. Signs to watch for include new or worsening depression, new or worsening anxiety, agitation, insomnia, hostility, panic attacks, restlessness, extreme hyperactivity, and suicidal thinking or behavior. This is very important when an antidepressant medicine is first started or when the dose is changed.

    Never combine Remeron with any drug classified as an MAOI, a class of drugs used to treat depression, psychiatric or emotional disorders, or Parkinson's disease. Remeron and MAOIs should not be taken together or within 14 days of each other. Combining these drugs with Remeron can cause serious and even fatal reactions such as high body temperature, muscle rigidity, twitching, and agitation, leading to delirium and coma.

    If you develop signs and symptoms of fever, sore throat, fever, inflammation of your mouth, or other signs of infection, contact your doctor immediately as this may be a sign of a serious side effect of Remeron.

    Remeron may cause a severe, possibly life-threatening condition called serotonin syndrome (a potentially life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by the nerve cells). Contact your doctor immediately if you experience any of the following symptoms: agitation, hallucinations, fast heartbeat, changes in blood pressure, increased body temperature, lack of coordination, or overactive reflexes.

    While you may feel better with Remeron therapy in 1 to 4 weeks, you should continue therapy as directed. Do not stop taking Remeron without first talking with your doctor as this can cause serious side effects.

    This drug may impair the mental and/or physical abilities required for performing potentially hazardous tasks such as driving or operating machinery. These effects may become worse if you combine Remeron with alcohol or certain medicines.

  • Who should not take Remeron?

    Remeron should not be used if you are allergic to this medication or any of its ingredients.

    Do not use Remeron if you have used MAOIs within the past 14 days.

  • What should I tell my doctor before I take the first dose of Remeron?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Remeron. Also, talk to your doctor about your complete medical history, especially if you have liver or kidney disease, a low white blood cell count, have taken an MAOI drug within the past 14 days, if you have high cholesterol, a history of seizures, heart problems, a history of bipolar disorder, or if you have attempted or thought about suicide in the past. Also tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended starting dose is 15 milligrams (mg) once a day taken as a single dose, preferably in the evening before you sleep. If necessary, your doctor may increase the dose up to 45 mg once a day. Changes in dose should not be made at intervals of less than 1 to 2 weeks.

    Elderly and people with serious liver or kidney problems may require a lower dose.

  • How should I take Remeron?

    Remeron should be taken exactly as prescribed. Do not stop taking Remeron without first talking with your doctor as this can cause serious side effects.

    Take Remeron by mouth in the evening before bedtime unless your doctor tells you otherwise.

    Improvements should be noticed within 1 to 4 weeks of taking Remeron. Continue to take Remeron even if you feel well; do not miss a dose.

  • What should I avoid while taking Remeron?

    Avoid driving or operating heavy machinery until you know how Remeron will affect you. Remeron may cause drowsiness and affect your mental and motor skills. Avoid alcohol while taking Remeron as it can worsen these side effects.

    Do not suddenly stop taking Remeron without talking to your doctor first as this can cause serious side effects.

  • What are possible food and drug interactions associated with Remeron?

    If Remeron is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Remeron with the following: alcohol, carbamazepine, cimetidine, diazepam, erythromycin, ketoconazole, linezolid, lithium, MAOIs, nefazodone, phenelzine, phenytoin, rifampicin, serotonin reuptake inhibitors, St. John's wort, tramadol, triptans, tranylcypromine, tryptophan, venlafaxine, and warfarin.

  • What are the possible side effects of Remeron?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: abnormal dreams, abnormal thinking, nausea, constipation, dizziness, drowsiness, confusion, dry mouth, flu symptoms, increased appetite, weakness, weight gain, mental or mood changes, mouth sores, thoughts of hurting yourself

  • Can I receive Remeron if I am pregnant or breastfeeding?

    The effects Remeron during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Remeron?

    If you miss a dose of Remeron, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Remeron?

    Store at room temperature.

Meet the Pharmacists

I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

Check out my latest blog post on antidepressants

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