What is Remodulin?Remodulin is a medicine used to treat pulmonary arterial hypertension (PAH), which is high blood pressure in the blood vessels between your heart and lungs, to diminish symptoms associated with exercise. This medication is also used to treat PAH in people who need to transition from Flolan (epoprostenol). Remodulin opens the blood vessels in your lungs and lowers your blood pressure. Remodulin is administered as a continuous subcutaneous (just below the skin) or intravenous (through a vein in your arm) infusion.
What is the most important information I should know about Remodulin?Long-term intravenous infusions of Remodulin using an indwelling central venous catheter (a tube that goes into a vein in your chest) is associated with the risk of sepsis (a bloodstream infection), which can be fatal. Therefore, your doctor will prefer to administer Remodulin subcutaneously.
Remodulin can cause strong widening effects on your blood vessels. Remodulin will be started in a setting where your doctor can carefully monitor your blood pressure and condition. Therapy with Remodulin can be used for prolonged periods, and your ability to administer Remodulin and care for an infusion system should be carefully considered by your doctor.
If you suddenly stop treatment with Remodulin, you can develop worsening of PAH symptoms. Do not suddenly stop using this medicine before talking to your doctor.
Who should not take Remodulin?Do not use Remodulin if you are allergic to it or any of its ingredients.
What should I tell my doctor before I take the first dose of Remodulin?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Remodulin. Also, talk to your doctor about your complete medical history, especially if you have kidney or liver problems, or low blood pressure.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: Your doctor will prescribe the appropriate dose for you and will increase your dose as needed, until the desired effect is achieved.
If you have mild or moderate liver impairment, your doctor will adjust your dose appropriately.
How should I take Remodulin?Use Remodulin exactly as prescribed by your doctor. Remodulin is infused continously through an infusion pump. Your doctor will instruct you on the proper way to prepare the infusion, as well as how to use the infusion pump.
What should I avoid while taking Remodulin?Do not miss your scheduled follow-up appointments with your doctor.
Do not admister Remodulin if the vial has particles or is discolored.
What are possible food and drug interactions associated with Remodulin?If Remodulin is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Remodulin with the following: blood pressure/heart medications, blood thinners (such as warfarin), diuretics (water pills) (such as furosemide), gemfibrozil, or rifampin.
What are the possible side effects of Remodulin?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: bleeding; bruising; diarrhea; dizziness; headache; infections; itching; jaw pain; low blood pressure; nausea; pain; rash; subcutaneous infusion-site pain, redness, or swelling; tingling sensations; vasodilation (widening of your blood vessels)
Can I receive Remodulin if I am pregnant or breastfeeding?The effects of Remodulin during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Remodulin?Remodulin should be administered as a continous infusion. If there is any lapse in time without receiving the medication, contact your doctor for advice.
How should I store Remodulin?Store the unopened vials at room temperature.