Generic Name: Rifampin

  • What is Rifamate?

    Rifamate is a medicine that combines two antibiotics, isoniazid and rifampin. Rifamate is used to treat a lung infection called tuberculosis.

  • What is the most important information I should know about Rifamate?

    Rifamate can cause severe liver impairment. Your risk can increase if you drink alcohol. Your doctor will monitor your liver function. Tell your doctor immediately if you experience tiredness, weakness, loss of appetite, nausea, or vomiting.

    Your urine, feces, saliva, sputum, sweat, and tears can be colored red-orange after you take Rifamate. In addition, your contact lenses can be permanently stained with this color.

  • Who should not take Rifamate?

    Do not take Rifamate if you are allergic to it or any of its ingredients. Also, do not take Rifamate if you currently have active liver disease, or have previously developed liver impairment or severe side effects (such as fever, chills, or arthritis) after using isoniazid.

  • What should I tell my doctor before I take the first dose of Rifamate?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Rifamate. Also, talk to your doctor about your complete medical history, especially if you have severe liver or kidney impairment, are malnourished, have diabetes or an increased risk of nerve disorders, are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended dose is two capsules once a day.

  • How should I take Rifamate?

    Take Rifamate exactly as prescribed by your doctor. You can take Rifamate one hour before or two hours after a meal.

    If needed, your doctor may suggest taking vitamin B6 while you are on Rifamate therapy.

  • What should I avoid while taking Rifamate?

    Do not drink alcohol while you are taking Rifamate.

  • What are possible food and drug interactions associated with Rifamate?

    If Rifamate is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Rifamate with the following: alcohol, birth control pills, blood thinners (such as warfarin), certain diabetes medications (such as metformin), corticosteroids (such as prednisone), dapsone, digoxin, disopyramide, methadone, phenytoin, or quinidine.

  • What are the possible side effects of Rifamate?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: allergic reactions, confusion, diarrhea, dizziness, drowsiness, fever, gas, headache, heartburn, inability to concentrate, loss of appetite, loss of coordination, nausea, nerve disorders, pain, rash, stomach discomfort, tiredness, visual disturbances, vomiting, weakness

  • Can I receive Rifamate if I am pregnant or breastfeeding?

    The effects of Rifamate during pregnancy and breastfeeding are unknown. Rifamate can be found in your breast milk if you take it during breastfeeding. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Rifamate?

    If you miss a dose of Rifamate, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Rifamate?

    Store in a dry place and away from excessive heat.