Aldactone

Generic name: Spironolactone

What is Aldactone?

Aldactone is used to control high blood pressure by flushing excess salt and water from the body and controls high blood pressure. This drug is also used in the treatment of hyperaldosteronism, a condition in which the adrenal gland secretes too much aldosterone (a hormone that regulates the body's salt and potassium levels). It is also used in treating other conditions that require the elimination of excess fluid from the body such as congestive heart failure, high blood pressure, cirrhosis of the liver, kidney disease, and unusually low potassium levels in the blood. When used for high blood pressure, Aldactone can be taken alone or with other high blood pressure medications.

What is the most important information I should know about Aldactone?

Aldactone only controls high blood pressure, it does not cure it. If you have high blood pressure, you must take Aldactone regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Aldactone; and you must continue taking it even if you are feeling well.

Who should not take Aldactone?

Do not begin treatment with Aldactone if you are allergic to any of its ingredients. Also, do not take this drug if you have kidney disease, an inability to urinate, difficulty urinating, or high potassium levels in your blood.

What should I tell my doctor before I take the first dose of Aldactone?

Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Aldactone. Also, talk to your doctor about your complete medical history, especially if you have kidney problems, liver disease, or you are going to have surgery or dental work while taking Aldactone.

What is the usual dosage?

The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Primary Hyperaldosteronism

Adults: The usual dosage of Aldactone is between 100 and 400 milligrams (mg) per day. In those who are not good candidates for surgery, this drug is given over the long term at the lowest effective dose.

Fluid Retention (Congestive Heart Failure, Cirrhosis of the Liver, or Kidney Disorders)

Adults: The usual starting dosage is 100 mg daily either in a single dose or divided into smaller doses.

High Blood Pressure

Adults: The usual starting dosage is 50 to 100 mg daily in a single dose or divided into smaller doses. This medication may be given with another diuretic or with other high blood pressure medications.

Potassium Loss

Adults: The usual dosage is 25 to 100 mg per day when potassium cannot be replaced with a supplement.

What should I avoid while taking Aldactone?

Avoid excessively sweating, and be sure to get enough of fluids. Dehydration (loss of water in the body) can cause your blood pressure to drop significantly.

What are possible food and drug interactions associated with Aldactone?

If Aldactone is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Aldactone with ACE inhibitors, alcohol, barbiturates such as Phenobarbital, digoxin, indomethacin, lithium, narcotic drugs such as those containing codeine, nonsteroidal anti-inflammatory drugs, norepinephrine, other diuretics, other high blood pressure medications, and steroids such as prednisone.

What are the possible side effects of Aldactone?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: breast development in males, deepening of voice, diarrhea, drowsiness, excessive hairiness, fever, headache, hives, irregular menstruation, lack of coordination, mental confusion, postmenopausal bleeding, severe allergic reaction, sexual dysfunction, skin eruptions, sleepiness, stomach bleeding, stomach cramps, stomach inflammation, ulcers, vomiting

Symptoms of potassium level changes: dry mouth, excessive thirst, weak or irregular heartbeat, muscle pain or cramps

Can I receive Aldactone if I am pregnant or breastfeeding?

The effects of Aldactone during pregnancy and breastfeeding are unknown. Talk with your doctor before taking this drug if you are pregnant, plan to become pregnant, or are breastfeeding.

What should I do if I miss a dose of Aldactone?

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

How should I store Aldactone?

Store at room temperature.