Arthrotec

Generic name: Diclofenac sodium and misoprostol

What is Arthrotec?

Arthrotec is designed to relieve the symptoms of arthritis in people who are also prone to ulcers. It contains diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) for control of the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis. However, since NSAIDs can cause stomach ulcers in susceptible people, Arthrotec also contains misoprostol, a synthetic prostaglandin that serves to reduce the production of stomach acid, protect the stomach lining, and thus prevent ulcers.

What is the most important information I should know about Arthrotec?

Be certain to avoid taking Arthrotec during pregnancy. It can cause a miscarriage with potentially dangerous bleeding, sometimes leading to hospitalization, surgery, infertility, and even death. Arthrotec can also deform or kill the developing baby. If you haven't passed menopause, your doctor should do a pregnancy test less than 2 weeks before your therapy begins. Once you've started taking the drug, it is vitally important that you also use reliable contraceptive measures. If you do become pregnant, stop taking Arthrotec and contact your doctor immediately.

Who should not take Arthrotec?

Remember that it is essential to avoid Arthrotec during pregnancy. You should also avoid this medication if you've ever had an allergic reaction to either of its components (diclofenac and misoprostol). Avoid it, too, if you've had a reaction to any other prostaglandin medication, or to any NSAID, including aspirin. Make sure the doctor is aware of any drug reactions you've experienced.

What should I tell my doctor before I take the first dose of Arthrotec?

Tell your doctor about all prescription, over-the-counter, and herbal medication you are taking before beginning treatment with Arthrotec. Also, talk to your doctor about your complete medical history, especially if you have kidney or liver disease, lupus or another connective tissue disease, severe vomiting or diarrhead, or you have porphyria.

What is the usual dosage?

The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Osteoarthritis

Adults: The recommended dose is 50 milligrams (mg) 3 times daily.

Rheumatoid Arthritis

The recommended dose is 50 mg 3 or 4 times daily.

If you can not tolerate the recommended dosage, your doctor can prescribe a dose of 50 or 75 mg twice daily. However, such lower dosages are less effective at preventing ulcers.

How should I take Arthrotec?

To minimize diarrhea and related side effects, take Arthrotec with meals, exactly as prescribed. Antacids containing magnesium can make Arthrotec-induced diarrhea worse. If you need an antacid, use one containing aluminum or calcium instead. Arthrotec tablets should be swallowed whole and not chewed, crushed, or dissolved.

What should I avoid while taking Arthrotec?

What are possible food and drug interactions associated with Arthrotec?

If Arthrotec is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Arthrotec with the following: aspirin; blood pressure medications such as diltiazem hydrochloride, enalapril maleate, nifedipine, and propranolol hydrochloride;cyclosporine; digoxin; diuretics; glipizide; glyburide; insulin; lithium; magnesium-containing antacids; methotrexate; phenobarbital; prednisolone; and warfarin.

What are the possible side effects of Arthrotec?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: abdominal pain, acid indigestion, diarrhea, gas, nausea

Can I receive Arthrotec if I am pregnant or breastfeeding?

Do not begin treatment with Arthrotec if you are pregnant, plan to become pregnant, or you are breastfeeding. Use reliable contraception while you are being treated with Arthrotec. This drug appears in breast milk, so your doctor may have you stop breastfeeding until your treatment with Arthrotec is finished.

What should I do if I miss a dose of Arthrotec?

If you are following a regular schedule, take the dose as soon as you remember. If it is almost time for the next one, skip the dose you missed and go back to your regular schedule. Do not take 2 doses at once.

How should I store Arthrotec?

Store at room temperature in a dry place.