Efudex

Generic name: Fluorouracil

What is Efudex?

Efudex is a topical treatment for precancerous actinic keratoses (AKs) and superficial basal cell carcinoma (sBCC), common forms of skin cancer. These lesions are caused by sun exposure.

AKs first appear as small tan, brown, or reddish-brown patches. They can be as small as a few millimeters, be flat or raised, and have a white scaly top that's rough to the touch.

sBCC is a sun-induced skin cancer most often found above the neckline, on the bridge of the nose or around the eye. The lesions appear as scaly, red, flat areas with a threadlike border. Superficial basal cell carcinoma usually occurs as multiple lesions in clusters on the skin.

What is the most important information I should know about Efudex?

Efudex should not be used in women who are pregnant or plan to become pregnant. This drug may cause severe deformities to an unborn child.

Also, this drug should only be applied topically (on the skin), not on any mucous membranes (eg, lips, eyes). During pregnancy, cases of miscarriage have been associated with Efudex application to mucous membranes.

Who should not take Efudex?

Do not begin treatment with Efudex if you are a pregnant or plan to become pregnant. (See "Can I receive this medication if I am pregnant or breastfeeding?" below for more information.)

Do not take Efudex if you are allergic to any of its ingredients.

What should I tell my doctor before I take the first dose of Efudex?

Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Efudex. Also, talk to your doctor about your complete medical history, especially if you are pregnant, plan to become pregnant, or nursing. This drug may cause severe harm to your unborn baby.

What is the usual dosage?

The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Actinic Keratoses (AKs)

Adults: The usual application of Efudex is twice a day for 2-4 weeks. Complete healing of lesions may not be seen until 1 -- 2 months after completion of therapy.

Superficial basal cell carcinoma (sBCC)

Adults: The usual application is Efudex twice a day for at least 3-6 weeks, and up to 10-12 weeks.

How should I take Efudex?

Apply it to the affected areas twice a day, once in the morning and once in the evening. Use enough cream to cover the lesions, and be careful when applying near the eyes, nose, and mouth.

You may apply Efudex cream with a nonmetal applicator, a glove, or your fingertips. Be sure to wash your hands thoroughly after each application. To use Efudex solution, hold the container, which has a built in applicator, against the affected areas and squeeze until a small amount reaches the skin. Be careful when applying it near the eyes, nose, and mouth.

What should I avoid while taking Efudex?

Avoid becoming pregnant, or avoid taking Efudex while you are pregnant.

Avoid staying in the sun for prolonged periods of time; this may intensify the reaction between Efudex and your skin.

What are possible food and drug interactions associated with Efudex?

There are no reported food or drug interactions associated with Efudex. However, notify your doctor of all prescription and non-prescription medications or supplements you are currently taking.

What are the possible side effects of Efudex?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: allergic reactions, burning, crusting, irritation, itchiness, pain, rash, redness, scarring, sensitivity to light, skin color change, soreness, ulceration

Can I receive Efudex if I am pregnant or breastfeeding?

The effects of Efudex during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

What should I do if I miss a dose of Efudex?

If you miss a dose, skip it and apply at the next scheduled dosage time. Do not apply double the amount at once.

How should I store Efudex?

Store at room temperature.