Protonix

Generic name: Pantoprazole

What is Protonix?

Protonix is used to treat and maintain healing of erosive acid reflux disease, also known as erosive GERD (breaks in the lining of the esophagus) and to relieve associated symptoms that may include frequent and persistent heartburn and stomach acid backup. Protonix reduces the amount of acid your stomach produces

Protonix is also prescribed to maintain healing and to prevent a relapse of GERD. It is also used in the treatment of conditions marked by constant overproduction of stomach acid, such as Zollinger-Ellison syndrome.

What is the most important information I should know about Protonix?

Swallow Protonix tablets whole. Do not crush, chew, or split the tablets. They are formulated to release the medication slowly in the body.

Who should not take Protonix?

Do not take Protonix if you are allergic to the medication or any or its ingredients.

What should I tell my doctor before I take the first dose of Protonix?

Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Protonix. Also, talk to your doctor about your complete medical history, especially if you have liver disease.

What is the usual dosage?

The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Erosive Esophagitis

Adults: The usual dose is 40 milligrams (mg) once a day for up to 8 weeks. If your esophagus hasn't healed in that time, your doctor may prescribe an additional 8-week course of therapy. The same dose is used to maintain healing.

Zollinger-Ellison Syndrome (Overproduction of Stomach Acid)

Adults: The usual starting dose is 40 mg twice a day. The doctor may increase the dose if necessary. Doses as high as 240 mg per day have been used. Treatment may continue for years.

The safety and effectiveness of Protonix in children has not been established.

How should I take Protonix?

Protonix may be taken with or without food. Do not chew, crush, or split the delayed-release tablets. If patients are unable to swallow a 40-mg tablet, two 20-mg tablets may be taken.

Protonix Delayed-Release Oral Suspension should be administered in applesauce or apple juice approximately 30 minutes prior to a meal. To administer with applesauce, open packet and sprinkle intact granules on 1 teaspoonful of applesauce. Swallow within 10 minutes of preparation.

To administer in apple juice, open packet, empty intact granules into a small cup containing 5 mL of apple juice (approximately 1 teaspoonful). Stir for 5 seconds and swallow immediately. To ensure complete delivery of the dose, rinse the container once or twice with apple juice to remove any remaining granules and swallow immediately.

What should I avoid while taking Protonix?

There are no restrictions on food, beverages, or activity while taking Protonix, unless otherwise directed by your doctor.

What are possible food and drug interactions associated with Protonix?

If Protonix is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Protonix with ampicillin, iron, ketoconazole, or warfarin.

What are the possible side effects of Protonix?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: abdominal pain, diarrhea, gas, headache, rash

Can I receive Protonix if I am pregnant or breastfeeding?

The effects of Protonix during pregnancy are unknown. Tell your doctor immediately if you are pregnant, or plan to become pregnant. There is a possibility that Protonix may appear in breast milk, causing serious side effects in the nursing infant. If you have to take the drug, you should not plan on breastfeeding.

What should I do if I miss a dose of Protonix?

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at once.

How should I store Protonix?

Store Protonix at room temperature.