Tranxene

Generic name: Clorazepate dipotassium

What is Tranxene?

Tranxene T-Tab and Tranxene tablets belong to a class of drugs known as benzodiazepines. Tranxene is used to treat anxiety disorders and for the short-term relief of anxiety symptoms. The drug is also used to relieve the symptoms of acute alcohol withdrawal and to help in treating certain convulsive disorders such as epilepsy.

What is the most important information I should know about Tranxene?

Tranxene may be habit-forming if taken regularly over a long period. You may experience withdrawal symptoms if you stop using this drug abruptly. Consult your doctor before discontinuing Tranxene or making any change in your dose.

This drug has not been studied in children less than 9 years old.

Who should not take Tranxene?

Do not use Tranxene if you have a known hypersensitivity to the drug or if you have an eye condition known as acute narrow-angle glaucoma.

What should I tell my doctor before I take the first dose of Tranxene?

Tell your doctor about all prescription, over-the-counter, and herbal medication you are taking before beginning treatment with Tranxene. Also, talk to your doctor about your complete medical history, especially if you are being treated for depression or anxiety or if you have a history of drug abuse or dependence.

What is the usual dosage?

The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Anxiety

Adults: Tranxene T-Tab is administered orally in divided doses. The usual daily dose is 30 milligrams (mg). The dose should be adjusted gradually within the range of 15-60 mg daily depending on your response. In elderly or debilitated patients, treatment may start at a daily dose of 7.5-15 mg. It can be given as a single dose at bedtime starting at 15 mg. Tranxene tablets may be given as a single dose every 24 hours after you are stable on a fixed dose divided throughout the day and can be switched to a once daily dose for convenience.

Alcohol Withdrawal Symptoms

Adults: The doctor will provide a schedule of reducing daily doses until your condition is stable.

Add-on Therapy with Antiepileptic Drugs

Adults and children over 12 years old: The starting dose is 7.5 milligrams (mg) 3 times a day. Your doctor may increase the dosage by 7.5 mg per week to a maximum of 90 mg a day.

Children 9-12 years old: The starting dose is 7.5 mg 2 times a day. Your doctor may increase the dosage by 7.5 mg per week to a maximum of 60 mg a day.

How should I take Tranxene?

Take Tranxene exactly as prescribed. Do not increase the amount you take or the number of doses per day without your doctor's approval.

What should I avoid while taking Tranxene?

Avoid driving a car or operating machinery until you know how Tranxene affects you. Also avoid alcohol and other central nervous system depressants while taking this drug.

What are possible food and drug interactions associated with Tranxene?

If Tranxene is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Always check with your doctor before combining Tranxene T-Tabs with the following: antidepressants including monoamine oxidase inhibitors or tricyclics, antipsychotics, barbiturates, narcotic pain relievers, and alcohol or other central nervous system depressants.

What are the possible side effects of Tranxene?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: drowsiness, dizziness, stomach complaints, nervousness, blurred vision, dry mouth, headache, mental confusion

Can I receive Tranxene if I am pregnant or breastfeeding?

Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding before taking this drug. Several studies have suggested an increased risk of birth defects associated with using minor tranquilizers during the first trimester of pregnancy. Because treatment with minor tranquilizers is rarely a matter of urgency, their use during this period should almost always be avoided. Tranxene should not be given to nursing mothers.

What should I do if I miss a dose of Tranxene?

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

How should I store Tranxene?

Store at room temperature in a tightly closed, light-resistant container. Protect from moisture and excessive heat.