Zofran

Generic name: Ondansetron hydrochloride

What is Zofran?

Zofran helps prevent nausea or vomiting in patients who are receiving chemotherapy or radiation. It may be taken with initial or repeated courses of chemotherapy, as well as to prevent nausea or vomiting after surgery.

What is the most important information I should know about Zofran?

Taking Zofran after you have had abdominal surgery, or to prevent nausea or vomiting from chemotherapy, may mask the signs and symptoms of stomach distension (bloating) or a disorder of the intestines known as progressive ileus. This drug may cause irregular heartbeats or rhythms, especially if you are receiving it by injection. If you have phenylketonuria (inability to break down amino acids), it is important to know that Zofran ODT (orally disintegrating tablets) contains phenylalanine (less than 0.03 milligrams).

Who should not take Zofran?

Do not take Zofran if you are allergic to it or sensitive to any of its ingredients, or any other similar medication known as a 5HT-3 antagonist.

What should I tell my doctor before I take the first dose of Zofran?

Mention all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zofran. Also, talk to your doctor about your complete medical history, especially if you have any type of stomach or intestinal problems.

What is the usual dosage?

The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Prevention of Nausea and Vomiting Due to Cancer Chemotherapy

Adults: The usual dose is 8 milligrams (mg) taken twice a day. The first dose should be taken 30 minutes before the start of chemotherapy, with the second dose 8 hours after the first dose. Then, 8 mg is taken every 12 hours for 1 to 2 days after completion of chemotherapy.

Children 12 years and older: The usual dose is 8 mg taken twice a day. The first dose should be given 30 minutes before the start of chemotherapy, with the second dose 8 hours after the first dose. Then, 8 mg is taken every 12 hours for 1 to 2 days after completion of chemotherapy.

Children 4 to 11 years old: The usual dose is 4 mg given 3 times a day. The first dose should be given 30 minutes before the start of emetogenic chemotherapy, with additional doses 4 and 8 hours after the first dose. Also, 4 mg may be given 3 times a day (every 8 hours) for 1 to 2 days after completion of chemotherapy.

Prevention of Nausea and Vomiting Due to Radiation Therapy

Adults: The usual dose is 8 mg taken 3 times a day, 1 to 2 hours before each treatment. Depending on your therapy regimen, you may need to take additional doses every 8 hours after therapy is done as prescribed by your doctor.

Postoperative Nausea and Vomiting

Adults: The usual dose is 16 mg taken 1 hour before you are put under anesthesia for surgery.

Patients with Hepatic Impairment

Do not exceed 8 mg a day.

How should I take Zofran?

Zofran must be taken exactly as prescribed, with or without food. The Zofran ODT should not be pushed through the foil wrapping. With dry hands, carefully peel back the foil and place the tablet on the tip of the tongue, where it will dissolve, then swallow. Do not remove the foil packaging until it is time to take the medication.

What should I avoid while taking Zofran?

Do not take more Zofran than prescribed unless directed by your doctor.

What are possible food and drug interactions associated with Zofran?

If Zofran is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zofran with the following: carbamazepine, phenytoin, rifampicin, or tramadol.

No dosage adjustments of Zofran are necessary.

What are the possible side effects of Zofran?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: constipation, diarrhea, drowsiness, dizziness, fatigue, headache, impaired wound healing, itch, decreased heart rate, fever, anxiety/agitation

Can I receive Zofran if I am pregnant or breastfeeding?

The effects of Zofran during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

What should I do if I miss a dose of Zofran?

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not double the dose.

How should I store Zofran?

Store at room temperature and protect it from light.