AcipHex

Generic name: Rabeprazole sodium

What is AcipHex?

AcipHex is used to treat gastroesophageal reflux disease (GERD), secretion problems like Zollinger-Ellison syndrome, and with clarithromycin and amoxicillin for ulcers of the small intestine. GERD is caused by the constant backflow of stomach acid into your throat. Zollinger-Ellison syndrome occurs when the stomach begins to produce too much acid.

Also, AcipHex is sometimes combined with the antibiotics amoxicillin and clarithromycin to treat infections caused by H. pylori, a type of bacteria that lives in the digestive tract and is often associated with recurrent ulcers.

What is the most important information I should know about AcipHex?

To treat ulcers of the small intestine, AcipHex should not be taken with clarithromycin if you are pregnant. Clarithromycin may cause harm to the unborn child. Amoxicillin should not be taken at the same time as penicillin; this combination may have a fatal interaction.

Who should not take AcipHex?

Do not begin treatment with AcipHex if you are allergic to any of its ingredients. Also, this drug should not be used if you are already taking medications containing cisapride or pimozide.

What should I tell my doctor before I take the first dose of AcipHex?

Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with AcipHex. Also, talk to your doctor about your complete medical history, especially if you have ulcers caused by H. pylori. Alone, AcipHex may make these ulcers worse, so an antibiotic should be prescribed to take with this drug.

What is the usual dosage?

The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Healing and Maintenance of GERD

Adults: The recommended dose is one 20 milligrams (mg) delayed-release tablet taken once daily for 4-8 weeks.

Healing of Duodenal Ulcers

Adults: The recommended dose is one 20 mg delayed-release tablet to be taken once daily after the morning meal for a period up to 4 weeks.

Treatment of Zollinger-Ellison Syndrome

Adults: The recommended dose is 60 mg once per day.

How should I take AcipHex?

AcipHex alone may be taken with or without food. All three medications (AcipHex, amoxicillin, clarithromycin) should be taken twice daily with the morning and evening meals.

What should I avoid while taking AcipHex?

Do not crush, split, or chew the tablets.

What are possible food and drug interactions associated with AcipHex?

If AcipHex is taken with certain other drugs, the effects of either could be increase, decreased, or altered. It is especially important to check with your doctor before combining AcipHex with cyclosporine, digoxin, ketoconazole, or warfarin.

What are the possible side effects of AcipHex?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: allergic reaction, bone pain, chest pain, chills, constipation, diarrhea, dry mouth, fever, gas, leg cramps, light sensitivity, migraines, nausea, sore throat, upset stomach, vomiting

Can I receive AcipHex if I am pregnant or breastfeeding?

The effects of AcipHex during pregnancy and breastfeeding are unknown. Talk with your doctor before taking this drug if you are pregnant, plant to become pregnant, or are breastfeeding.

What should I do if I miss a dose of AcipHex?

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take two doses at once.

How should I store AcipHex?

Store at room temperature, away from moisture.