Dacogen

Generic name: Decitabine

What is Dacogen?

Dacogen is used for the treatment of myelodysplastic syndromes (MDS). MDS occurs when the bone marrow production of blood cells is disrupted, such as in refractory anemia (RA).

What is the most important information I should know about Dacogen?

Pregnant women should not begin treatment with Dacogen; this drug may cause developmental problems during the pregnancy. Also, men taking Dacogen should not father a child during or 2 months after treatment.

Who should not take Dacogen?

Do not take Dacogen if you are allergic to decitabine.

What should I tell my doctor before I take the first dose of Dacogen?

Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking to prevent a possible interaction with Dacogen. Also, talk to your doctor about your complete medical history, especially if you have kidney or liver problems, are pregnant, or planning to become pregnant.

What is the usual dosage?

The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Adults: The first treatment cycle with Dacogen is 15 milligrams (mg)/m² by continuous IV for 3 hours, every 8 hours for 3 days. This cycle may be repeated every 6 weeks for a minimum of 4 cycles. However, a complete or partial response may take longer than 4 cycles. Treatment may be continued as long as the patient continues to benefit. You may be given an anti-nausea medication before beginning therapy with Dacogen.

How should I take Dacogen?

Dacogen will be administered to you in a hospital setting.

What should I avoid while taking Dacogen?

While being treated with Dacogen, avoid pregnancy, nursing, or fathering a child. The effects of Dacogen on an unborn baby are hazardous to its development. For men, avoid fathering a child while receiving treatment with Dacogen and for 2 months afterward.

What are the possible side effects of Dacogen?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: neutropenia (low amount of neutrophils, a type of white blood cell), thrombocytopenia (low amount of platelets), anemia (low amount of hemoglobin, a molecule inside a red blood cell), constipation, cough, diarrhea, fever, increase in blood sugar level, nausea, purple-colored blotches on the skin, fatigue

Can I receive Dacogen if I am pregnant or breastfeeding?

Do not begin treatment with Dacogen if you are pregnant, plan to become pregnant, or nursing. Dacogen may cause developmental problems in your unborn child, and may pass into breast milk.

Also, if you are male, do not father a child while on Dacogen or for 2 months after finishing treatment with this drug. Developmental problems may occur during the pregnancy.

What should I do if I miss a dose of Dacogen?

Dacogen will be administered to you in a hospital setting. Do not miss any appointments, or call your doctor if you think you might.

How should I store Dacogen?

Dacogen will be administered to you in a hospital setting.