Elaprase

Generic name: Idursulfase

What is Elaprase?

Elaprase is used to treat Hunter syndrome, also known as mucopolysaccaridosis II. This syndrome is genetic, and occurs when there is not an enzyme present to breakdown complex carbohydrates in the body. These carbohydrates begin to build in the organs and become toxic. Elaprase acts as the enzyme to break down these hazardous carbohydrates.

What is the most important information I should know about Elaprase?

There is a high risk of allergic reaction associated with Elaprase infusion. Appropriate medical support is necessary. People with respiratory problems need monitoring while taking Elaprase due to the increased risk of life-threatening reactions.

Who should not take Elaprase?

You should not take Elaprase if you are allergic to any of its ingredients.

What should I tell my doctor before I take the first dose of Elaprase?

Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking. Also, talk to your doctor about your complete medical history, especially if you are pregnant or planning to become pregnant. Your doctor should discuss the potential for passing Hunter syndrome to your children.

What is the usual dosage?

The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

The recommended dosage of Elaprase is 0.5 milligrams (mg)/kilogram (kg) of body weight given every week through intravenous infusion.

How should I take Elaprase?

You will be given your weekly dose of Elaprase intravenously at a treatment center. The infusion takes up to 3 hours, but may take longer if infusion reactions occur. Infusion should not exceed 8 hours.

What should I avoid while taking Elaprase?

The treatment center giving the dose should avoid infusing Elaprase with other products in the infusion tubing. Each vial is for single use only.

What are possible food and drug interactions associated with Elaprase?

No food or drug interaction studies have been conducted.

What are the possible side effects of Elaprase?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: fever, headache, joint pain, increased blood pressure, itching, problems seeing, tiredness, wheezing

Can I receive Elaprase if I am pregnant or breastfeeding?

The effects of Elaprase during pregnancy and breastfeeding are unknown. Talk with your doctor before taking this drug if you are pregnant, plan to become pregnant, or are breastfeeding.

What should I do if I miss a dose of Elaprase?

Notify your doctor immediately if you miss your scheduled weekly visit. Your doctor may slow the infusion rate, temporarily stop, or discontinue treatment at your visit if infusion reactions occur. Your doctor will decide whether you should continue treatment.

How should I store Elaprase?

The treatment center performing the infusion will store this medication. Elaprase should be refrigerated and protected from light. The vial should not be frozen or shaken. Elaprase should not be used after the expiration date on the vial.