Iplex

Generic name: Mecasermin rinfabate [rDNA origin]

What is Iplex?

Iplex is an injectable prescription medicine that contains man-made insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3). Iplex is used to treat children with severe primary IGF-1 deficiency. Children with severe primary IGF-1 deficiency are very short for their age because their bodies do not make enough IGF-1.

What is the most important information I should know about Iplex?

Who should not take Iplex?

Your child should not take Iplex if he/she has finished growing (bone growth plates are closed), has cancer, or is allergic to mecasermin rinfabate.

What should I tell my doctor before my child takes the first dose of this medication?

Tell your child's healthcare professional about all of your child's health conditions, including if your child has diabetes, kidney problems, has liver problems, has a curved spine (scoliosis), or is pregnant or breastfeeding.

What is the usual dosage?

The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

The initial dose of Iplex is 0.5 milligrams (mg)/kilogram (kg) a day. This dosage is usually increased gradually to 1-2 mg/kg a day.

How should my child take this medication?

Remove Iplex from the freezer 45 minutes before it needs to be injected. If the liquid appears cloudy, throw it away. Injection sites include the thigh, abdomen, buttocks, and upper arm. Do not inject Iplex if it has been out of the freezer for more than 2 hours; discard it immediately. Do not re-freeze Iplex.

What should my child avoid while taking this medication?

Never inject Iplex into a vein or allow it to sit room temperature for more than 2 hours. Discard any solution that is cloudy or has anything floating in it.

What are possible food and drug interactions associated with Iplex?

Iplex may cause a severe drop in blood sugar. Make sure your child always has a sugar drink or food with them such as orange juice, hard candy, milk, or glucose gel.

What are the possible side effects of Iplex?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: Allergic reactions, enlarged tonsils, hip bone problems, low blood sugar, reactions to injection site, worsened curve in the spine (scoliosis)

Symptoms of low blood sugar include: Dizziness, fast or irregular heartbeat, headache, hunger, irritability, nausea, restlessness, sweating, tiredness, trouble concentrating,

Can my child receive this medication if she is pregnant or breastfeeding?

The effects of Iplex are unknown in pregnancy. If your child is pregnant or breastfeeding, talk to your doctor for the best possible therapy options.

What should I do if my child misses a dose of this medication?

If your child misses a dose of Iplex, do not make up for it. Continue on his/her regular dosing schedule.

Where should I keep my child's supply of this medication?

Store in the freezer. Do not allow to thaw until 45 minutes before scheduled usage.