Drugs and Supplements

Prescription Drugs

Lithium carbonate, side effects, drug interactions, overdose, dosage

Lithium carbonate


What is Lithium carbonate?

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Lithium is used in the treatment of manic episodes of patients with bipolar disorder. A manic episode is a time of abnormally elevated, unreserved, or irritable mood.

Lithium is also used in the maintenance treatment of patients diagnosed with bipolar disorder.


What is the most important information I should know about Lithium carbonate?

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It may take up to 3 weeks before you see any improvement in your symptoms.

While taking lithium, it is very important that you follow your doctor's recommendations and make sure you do not miss any appointments or laboratory tests.

Toxic levels of this medication can occur at any dose and frequent blood tests will be required. You should stop taking lithium carbonate and contact your doctor immediately if you develop signs of lithium toxicity such as diarrhea, vomiting, tremor, mild lack of coordination, drowsiness, and muscular weakness.

The safety and efficacy of this medication is unknown in children under 12 years of age, and its use is not recommended.


Who should not take Lithium carbonate?

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Do not take this medication if you are allergic to lithium, Lithobid, Eskalith, Eskalith CR, or any of their components.


What should I tell my doctor before I take the first dose of Lithium carbonate?

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Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with lithium. Also, talk to your doctor about your complete medical history, especially if you have a history of kidney or heart disease, thyroid problems, severe debilitation, dehydration, low sodium levels, and if you are pregnant, plan to become pregnant, or are breastfeeding.


What is the usual dosage?

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The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Acute Mania in Bipolar Disorder

Adults: The optimal daily dose is 1,800 milligrams (mg), taken in divided doses of one 600-mg capsule three times a day. This medication is also available in liquid form; the optimal dose is 30 mL daily taken as 2 full teaspoons three times a day.

Maintenance Therapy for Bipolar Disorder

Adults: The optimal dose is different from one individual to another; however, the usual dose is 900-1,200 mg daily taken as 300-mg tablets three or four times daily. If you are taking the liquid form, the recommended dose is 1 full teaspoon taken three or four times daily.


How should I take Lithium carbonate?

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Lithium capsules or tablets should be swallowed whole and should never be chewed or crushed. If you are taking the liquid form, do not take more than your recommended dose.


What should I avoid while taking Lithium carbonate?

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You should never stop taking this medication without consulting your doctor first. Driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness should be avoided until you know how this drug affects you.


What are possible food and drug interactions associated with Lithium carbonate?

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If lithium is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining this medication with the following: acetazolamide, antidepressants, blood pressure medications, carbamazepine, desmopressin, haloperidol, methyldopa, metronidazole, monoamine oxidase inhibitors (MAOIs), methyldopa, nonsteroidal anti-inflammatory drugs (NSAIDs), phenytoin, potassium iodide, sodium bicarbonate, and urea.


What are the possible side effects of Lithium carbonate?

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Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: fine hand tremor, frequent urination, temporary and mild nausea, general discomfort

Serious side effects that may signal lithium intoxication: diarrhea, vomiting, drowsiness, muscular weakness, lack of coordination

Contact your doctor immediately if you experience any serious symptoms.


Can I receive Lithium carbonate if I am pregnant or breastfeeding?

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Lithium should not be used during pregnancy as there is a risk of fetal death. Lithium is excreted in breast milk. Since the effects are unknown, lithium should be avoided during breastfeeding. If you are pregnant, plan to become pregnant, or are breastfeeding, tell your doctor immediately.


What should I do if I miss a dose of Lithium carbonate?

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If you miss a dose of this drug, skip it. Never take an extra dose to make up for a missed dose.


How should I store Lithium carbonate?

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Store at room temperature in a dry place and away from light.