Vivaglobin

Generic name: Immune globulin subcutaneous (human)

What is Vivaglobin?

Vivaglobin is an immunoglobin injected subcutaneously for patients with primary immunodeficiency (PI). The immune system acts to protect the body against infections caused by bacteria and viruses. In the immune system, white blood cells and antibodies called immunoglobulins (Ig) identify and destroy these harmful invaders. Those who have PI have incomplete immune systems that are not working properly. Thus, Ig therapy can help build up a weakened immune system.

What is the most important information I should know about Vivaglobin?

Vivaglobin is derived from human plasma blood components. There is a risk of getting certain viruses that cannot be removed during the manufacturing process. Risk is reduced by screening blood donors for current infections or exposure to certain viruses.

If you are receiving Ig therapy for the first time, are new to Vivaglobin, or have not received Ig therapy within the past eight weeks, your healthcare provider will monitor your initial treatment, as you could experience reactions including fever, chills, nausea, and vomiting. Rarely, these reactions may lead to shock.

Ig administration may impair the effectiveness of virus vaccines, such as measles, mumps, and rubella. Consult your doctor if you plan to receive any vaccine.

Who should not take Vivaglobin?

Immune globulin products, such as Vivaglobin, should not be taken if you have a history of anaphylactic or severe systemic response to immunoglobulin preparations. If you suspect you are having a severe reaction to Vivaglobin, discontinue treatment immediately and inform your doctor.

What should I tell my doctor before I take the first dose of Vivaglobin?

Mention all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Vivaglobin. Also, talk to your doctor about your complete medical history, especially if you have a weakened immune system, have had previous treatment with immunoglobulins, and recent vaccinations.

What is the usual dosage?

The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

It is recommended that patients should start Vivaglobin at least one week after receiving a regularly scheduled immunoglobulin IV infusion. The initial dose of Vivaglobin should be calculated by your doctor depending on the dose of the IV infusion in order to maintain adequate drug levels in the body.

The recommended weekly dose of Vivaglobin is 100-200 mg per 2.2 pounds of body weight subcutaneously for patients greater than 2 years old.

How should I take Vivaglobin?

Vivaglobin is infused just under the skin into fatty tissue in the thighs, upper arms, stomach, or hips. Do not inject into the blood vessels. This medication will be given under the supervision of your healthcare provider. He or she should show you the step-by-step process on how to use this medication at home.

What should I avoid while taking Vivaglobin?

Vivaglobin may decrease the efficacy of live vaccines such as the one that protects you against measles, mumps, and rubella. If you are receiving a vaccine, tell your healthcare provider that you have recently received therapy with Vivaglobin.

What are possible food and drug interactions associated with Vivaglobin?

If Vivaglobin is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Vivaglobin with live vaccines such as measles, mumps, and rubella.

What are the possible side effects of Vivaglobin?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: swelling, itchiness, redness at the injection site, headache, abdominal discomfort, fever, nausea, sore throat, rash

Can I receive Vivaglobin if I am pregnant or breastfeeding?

The effects of Vivaglobin during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding. Vivaglobin should only be used if the benefits outweigh the risks.

What should I do if I miss a dose of Vivaglobin?

Notify your healthcare provider if you have missed a dose of Vivaglobin.

How should I store Vivaglobin?

This medication will be stored by your healthcare provider.