Zoladex

Generic name: Goserelin acetate

What is Zoladex?

Zoladex is similar to a hormone chemical found in your body called gonadotropin releasing hormone (GnRH). This hormone is made by a gland in your brain that causes the release of several hormones, including testosterone. At first Zoladex may temporarily increase your levels of testosterone, but after a few weeks this drug will decrease them. Zoladex is used to treat advanced prostate cancer.

What is the most important information I should know about Zoladex?

Zoladex may temporarily increase your levels of testosterone, causing a short-term worsening of your symptoms, including additional signs or symptoms of prostate cancer, all which usually occur in the first few weeks of taking Zoladex. This drug can lead to a block in the outflow of urine from your bladder, or it may cause spinal cord compression. Zoladex may also cause an allergic reaction that can be life-threatening.

Who should not take Zoladex?

You should not take Zoladex if you are allergic or sensitive to any of its ingredients, or any luteinizing hormone-releasing hormone (LHRH) (also called GnRH agonists) agonist medication. Do not take Zoladex if you are pregnant, able to become pregnant, or breastfeeding.

What should I tell my doctor before I take the first dose of Zoladex?

Mention all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zoladex. Also, talk to your doctor about your complete medical history, especially if you have difficulty urinating or have any type of urinary blockage. Also, talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

What is the usual dosage?

The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Adults: The usual dose is 10.8 milligrams (mg) given subcutaneously every 12 weeks.

How should I take Zoladex?

Zoladex is usually given by a doctor or nurse, and is generally injected into the small layer of fat right under the skin in the front of the stomach.

What should I avoid while taking Zoladex?

What are possible food and drug interactions associated with Zoladex?

No confirmed interactions have been reported between Zoladex and other drugs.

What are the possible side effects of Zoladex?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: Breast enlargement, bone pain, hot flashes, pelvic pain, weakness, diarrhea, rectal bleeding, cystitis, anemia

Can I receive Zoladex if I am pregnant or breastfeeding?

Pregnancy Category: X

Zoladex is used in men with prostate cancer.

Female patients requiring treatment with goserelin should refer to the prescribing information for Zoladex 3.6 mg implant.

Zoladex should not be taken if you are pregnant or breastfeeding due to the harmful effects it may have on your unborn or nursing baby. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

What should I do if I miss a dose of Zoladex?

If you miss your Zoladex injection, contact your doctor right away. Depending on how much time has passed since your last injection, your doctor will determine the timing of your next dose.

How should I store Zoladex?

Store at room temperature.