Generic Name: Tramadol

  • What is Ryzolt?

    Ryzolt is an opioid painkiller that is used to treat moderate to moderately severe long-term pain that requires treatment for an extended period.

  • What is the most important information I should know about Ryzolt?

    Ryzolt can cause seizures. The risk is greater if you have a history of seizures, are suffering from alcohol or drug withdrawal (abrupt discontinuation or a decrease in the dose of medicines, recreational drugs, or alcohol you take), or nervous system infections. Your risk of seizures may also be increased if you are taking monoamine oxidase inhibitors (MAOIs), a class of medicines used to treat depression and other psychiatric conditions (such as phenelzine); antidepressant/psychiatric medicines in classes known as selective serotonin reuptake inhibitors (SSRIs) (such as fluoxetine or paroxetine), and selective norepinephrine reuptake inhibitors (SNRIs) (such as venlafaxine); certain antidepressants (such as amitriptyline); certain migraine products (such as sumatriptan); or other opioids.

    You can develop a serotonin syndrome (a potentially life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by the nerve cells) when you are using Ryzolt, especially if you take it in combination with MAOIs, SSRIs, SNRIs, certain migraine products, or certain antidepressants. Symptoms can include hallucinations, increase in your heart rate, fever, incoordination, and/or stomach problems. Contact your doctor immediately if you develop any of these signs or symptoms.

    Anaphylactoid reactions (a serious and rapid allergic reaction that may result in death if not immediately treated) can occur. Contact your doctor or get emergency help immediately if you experience difficulty breathing; swelling of the throat, tongue, or mouth; or hives.

    Taking Ryzolt can also lead to abuse, addiction, and dependence.

  • Who should not take Ryzolt?

    Do not take Ryzolt if you have attempted suicide or are addiction prone. Do not take Ryzolt if you are allergic to it or any of its ingredients, or to other opioids.

  • What should I tell my doctor before I take the first dose of Ryzolt?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Ryzolt. Also, talk to your doctor about your complete medical history, especially if you have a history of seizures, asthma, difficulty breathing, depression, head injury, kidney or liver disease, attempted suicide, or are addicted or allergic to opioids.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults ≥17 years: Your doctor will prescribe the appropriate dose for you and will increase your dose as needed, until the desired effect is achieved.

  • How should I take Ryzolt?

    Take Ryzolt exactly as prescribed by your doctor. Swallow the tablet whole with liquid. Do not chew, break, or split the tablet.

  • What should I avoid while taking Ryzolt?

    Do not drive a car or operate dangerous machinery while using Ryzolt.

    Do not drink alcohol while using Ryzolt.

    Do not adjust your dose or stop taking Ryzolt suddenly without first talking to your doctor.

  • What are possible food and drug interactions associated with Ryzolt?

    If Ryzolt is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Ryzolt with the following: alcohol, antidepressants (including MAOIs, SSRIs, SNRIs, and certain antidepressants), antipsychotics (such as haloperidol), carbamazepine, certain migraine products, cyclobenzaprine, digoxin, erythromycin, ketoconazole, linezolid, lithium, phenothiazines (such as promethazine), quinidine, rifampin, sleep aids (such as temazepam), St. John's wort, tranquilizers (such as alprazolam), or warfarin.

  • What are the possible side effects of Ryzolt?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: constipation, diarrhea, dizziness, drowsiness, dry mouth, headache, itching, nausea, sweating, vomiting, weakness

  • Can I receive Ryzolt if I am pregnant or breastfeeding?

    The effects of Ryzolt during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Ryzolt?

    If you miss a dose of Ryzolt, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Ryzolt?

    Store at room temperature.