Sabril Oral Solution

Generic Name: Vigabatrin

  • What is this medication and its most common uses?

    Sabril oral solution is used to treat seizures in infants and young children. It is available as a powder to be mixed with water.

  • What should I know when beginning and continuing on this medication?

    Sabril oral solution may only be available under a special restricted distribution program called the SHARE program. Under the SHARE program, only healthcare providers and pharmacies registered with the program are able to prescribe and distribute Sabril. In addition, you can only get Sabril oral solution if you are enrolled in and meet all conditions of SHARE. Your healthcare provider will explain the SHARE program to you. You will likely receive Sabril oral solution from a specialty pharmacy.

    How does this medication work?

    A seizure occurs when electrical signals in the brain are out of balance. Sabril oral solution is thought to be involved in the production of a chemical that helps to keep electrical signals balanced in the brain.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Sabril oral solution has been shown to lower the occurrence of seizures.

    When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that your child take Sabril oral solution exactly as the healthcare provider has prescribed.

    How do I know it is working?

    Your healthcare provider will ask you questions from time to time to assess how well your child's seizures are controlled.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Sabril oral solution can harm or affect your child's vision. Some people can have severe loss, particularly to their peripheral vision, in which they lose the ability to see to the side when looking straight ahead. If this happens, it will not get better. Your child may also experience blurry vision. Contact your healthcare provider right away if you think your child is not seeing as well as before he/she started taking Sabril oral solution; start to trip, bump into things, or are more clumsy than usual; or if your child is surprised by people or things coming in front of him/her that seem to come out of nowhere.

    More common side effects may include: sleepiness, ear infection, irritability.

    Less common side effects may include:

    Sabril oral solution can cause magnetic resonance imaging (MRI) changes. Brain pictures taken by MRI show changes in some babies after they are given Sabril oral solution.

    Sabril oral solution can increase the risk of suicidal thoughts or behavior. Tell your healthcare provider immediately if you notice any changes in your child's behavior.

    Sabril oral solution can cause anemia (low red blood cell counts); drowsiness and tiredness; numbness, pain or tingling in your child's hands or feet; weight gain; or swelling.

  • Who should not take this medication?

    Do not give Sabril oral solution to your child if he/she is allergic to it or any of its ingredients.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications your child is taking before beginning treatment with Sabril oral solution. Also, talk to your healthcare provider about his/her complete medical history, especially if he/she had an allergic reaction to Sabril oral solution (such as rash, itching, or trouble breathing), or has vision or kidney problems.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Infants and children 1 month-2 years: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight. Your healthcare provider may increase your child's dose as needed.

    If your child has kidney impairment, your healthcare provider may adjust his/her dose appropriately.

    It is important that you do not stop giving your child this medication abruptly. If your child needs to change or stop taking this medication, it is important that you only do this with the guidance of your healthcare provider.

  • How should I take this medication?

    Give Sabril oral solution to your child exactly as prescribed by your healthcare provider.

    Give Sabril oral solution twice a day, with or without food. It can be given at the same time as their food, but the powder should not be mixed with their food. Sabril oral solution should only be mixed with cold or room temperature water.

    Each dose should be prepared immediately before use and administered cold or at room temperature. Discard any unused medicine.

  • What should I avoid while taking this medication?

    Do not stop giving Sabril oral solution to your child, unless directed to do so by your healthcare provider.

  • What are the possible food and drug interactions associated with this medication?

    If Sabril oral solution is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Sabril oral solution with clonazepam or phenytoin.

  • May I receive this medication if I am pregnant or breastfeeding?

    Sabril oral solution is intended for use only by infants and young children.

  • What should I do if I miss a dose of this medication?

    If your child misses his/her scheduled dose of Sabril oral solution, contact your healthcare provider or pharmacist for advice.

  • How should I store this medication?

    Store at room temperature.