Generic Name: Salsalate

  • What is Salsalate?

    Salsalate is nonsteroidal anti-inflammatory drug (NSAID) used to treat signs and symptoms of rheumatoid arthritis, osteoarthritis, and related rheumatic disorders.

  • What is the most important information I should know about Salsalate?

    Salsalate can cause serious problems (such as heart attack or stroke). Your risk can increase when this medication is used for long periods of time and in people who have heart disease. Tell your doctor if you experience chest pain, shortness of breath, weakness, and slurred speech. Also, salsalate can cause high blood pressure or worsening of existing high blood pressure, and heart failure, which can lead to weight gain or edema (swelling).

    Salsalate can cause discomfort, ulcers, or bleeding in your stomach or intestines. Your risk can increase with long-term use, smoking, drinking alcohol, older age, or with certain medications. Tell your doctor immediately if you experience abdominal pain or if you have bloody vomit or stools.

    Long-term use of salsalate can cause kidney injury. Your risk can increase if you have kidney impairment; heart failure; liver problems; are taking certain medications, including diuretics (water pills) (such as furosemide) or blood/heart medications known as angiotensin-converting enzyme (ACE) inhibitors (such as lisinopril); are dehydrated; or are elderly. Also, salsalate can cause liver injury. Tell your doctor if you experience nausea, tiredness, weakness, itchiness, yellowing of your skin or whites of your eyes, right upper abdominal tenderness, or "flu-like" symptoms.

    Salsalate can cause allergic reactions resembling anaphylaxis (a serious and rapid allergic reaction that may result in death if not immediately treated). Stop taking salsalate and tell your doctor immediately if you experience difficulty breathing or swelling of your face, mouth, or throat. Tell your doctor immediately if you experience serious skin reactions, which can be characterized by a severe rash, fever, or itchiness.

  • Who should not take Salsalate?

    Do not take salsalate if you are allergic to it, any of its ingredients, or if you experienced asthma, rash, or allergic-type reactions after taking aspirin or other NSAIDs (such as ibuprofen).

    Do not take salsalate right before or after a heart surgery called a coronary artery bypass graft (CABG).

  • What should I tell my doctor before I take the first dose of Salsalate?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with salsalate. Also, talk to your doctor about your complete medical history, especially if you have any of the following: allergies to medications, history of asthma, high blood pressure, kidney disease, liver disease, stomach problems, or are pregnant, plan to become pregnant or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended dose is 3000 milligrams (mg) a day in divided doses. Your doctor will prescribe the appropriate number of tablets you need to take.

  • How should I take Salsalate?

    Take salsalate exactly as prescribed by your doctor.

  • What should I avoid while taking Salsalate?

    Do not take aspirin or other NSAIDs in combination with salsalate.

  • What are possible food and drug interactions associated with Salsalate?

    If salsalate is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining salsalate with the following: ACE inhibitors, aspirin, blood thinners (such as warfarin), diuretics, lithium, or methotrexate.

  • What are the possible side effects of Salsalate?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: abdominal pain, allergic reactions (such as rash), diarrhea, dizziness, hearing disturbances, high blood pressure, nausea, rash, ringing in your ear, swelling, vomiting

  • Can I receive Salsalate if I am pregnant or breastfeeding?

    Do not take salsalate if you are in the late stage of your pregnancy. The effects of salsalate during early pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Salsalate?

    If you miss a dose of salsalate, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Salsalate?

    Store at room temperature.