Sandostatin

Generic Name: Octreotide

  • What is Sandostatin?

    Sandostatin is a medicine used to treat acromegaly (a disease caused by the body making too much growth hormone) in people who have had inadequate response to or cannot tolerate other treatments such as surgery, radiation, or bromocriptine. Sandostatin is also used to treat severe diarrhea and flushing episodes associated with certain cancers (such as carcinoid tumors and VIPomas). Sandostatin is administered subcutaneously (just below the skin) or intravenously (through a vein in your arm).

  • What is the most important information I should know about Sandostatin?

    Sandostatin changes the balance between certain hormones (insulin, glucagon, and growth hormone), which can cause low or high blood sugar levels. Your doctor will monitor your blood sugar levels.

    Sandostatin can cause heart problems, hypothyroidism (an underactive thyroid gland), and can decrease your vitamin B12 levels during long-term treatment. Your doctor will be regularly checking your blood tests regularly.

    Acromegaly can cause you to become infertile during childbearing age. As Sandostatin normalizes your growth hormone levels, your fertility may be restored. It is recommended that you use adequate birth control during Sandostatin treatment.

  • Who should not take Sandostatin?

    Do not use Sandostatin if you are allergic to it or any of its ingredients.

  • What should I tell my doctor before I take the first dose of Sandostatin?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Sandostatin. Also, talk to your doctor about your complete medical history, especially if you have diabetes; gallbladder, heart, or thyroid problems; or are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Acromegaly

    Adults: The recommended starting dose is 50 micrograms (mcg) three times a day.

    Your doctor will prescribe the appropriate dose for you and will increase your dose as needed until the desired effect is achieved.

    Carcinoid Tumors

    Adults: The recommended starting dose is 100-600 mcg a day in 2-4 divided doses for the first 2 weeks.

    Your doctor may then give you a higher or lower dose depending on your needs.

    VIPomas

    Adults: The recommended starting dose is 200-300 mcg a day in 2-4 divided doses for the first 2 weeks.

    Your doctor may then give you a higher or lower dose depending on your needs.

  • How should I take Sandostatin?

    Use Sandostatin exactly as prescribed by your doctor. Do not use extra doses or inject more often without asking your doctor.

    Your doctor will teach you or your caregiver how to inject Sandostatin.

    You can reduce the pain of subcutaneous administration by using the smallest volume of Sandostatin that will deliver the appropriate dose. You also have to rotate your injection sites.

    Please review the instructions that came with your prescription on how to properly prepare and inject Sandostatin.

  • What should I avoid while taking Sandostatin?

    Do not inject multiple subcutaneous doses in the same site within short periods of time.

    Do not use Sandostatin for a condition for which it was not prescribed.

    Do not give Sandostatin to other people, even if they have the same symptoms you have.

  • What are possible food and drug interactions associated with Sandostatin?

    If Sandostatin is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to tell your doctor if you are taking any of the following prior to treatment with Sandostatin: blood pressure/heart medications known as beta-blockers (such as propranolol) or calcium channel blockers (such as diltiazem); bromocriptine; cyclosporine; insulin; medications that control fluid and electrolyte (chemicals that are important for the cells in your body to function, such as sodium and potassium) balance; oral antidiabetic medications; quinidine; or terfenadine.

  • What are the possible side effects of Sandostatin?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: abdominal discomfort, abnormal stools, back pain, blurred vision, constipation, diarrhea, dizziness, gallbladder problems, gas, hair loss, headache, hypothyroidism, injection-site pain, joint pain, low or high blood sugar levels, nausea, rash, slow heart rate, tiredness, vomiting

  • Can I receive Sandostatin if I am pregnant or breastfeeding?

    The effects of Sandostatin during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Sandostatin?

    If you miss a dose of Sandostatin, inject it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not inject two doses at once.

    Do not miss your follow-up appointments with your doctor.

  • How should I store Sandostatin?

    Store in the refrigerator. Protect from light.

    Store at room temperature for 14 days; the medication must be protected from light.