Generic Name: Clomiphene

  • What is Serophene?

    Serophene is used for the treatment of ovulatory dysfunction in women who want to become pregnant. Serophene works by stimulating the body to release follicle stimulating hormone and luteinizing hormone, the hormones necessary for ovulation to occur.

  • What is the most important information I should know about Serophene?

    As with other fertility medications, the use of Serophene is associated with multiple births (eg, twins, triplets). Do not use Serophene if you are already pregnant, as it may cause severe birth defects in your child, such as heart problems, Down syndrome, club foot, cleft palate, harelip, or webbed fingers/toes.

    Prolonged use of this drug may increase the risk of developing ovarian cancer.

    Serophene may cause you to have blurred vision and to see spots. These symptoms may cause problems when driving a car or operating machinery.

    Also, this drug may cause ovarian hyperstimulation syndrome (OHSS). (Please see "What are the possible side effects of this medication?" below for more information on the symptoms of OHSS.)

  • Who should not take Serophene?

    Do not take Serophene if you are allergic to any of its ingredients. Also, do not use this drug if you are pregnant, as it may cause harm to your unborn baby. Serophene should not be used in patients with liver disease, abnormal uterine bleeding, ovarian cysts, and in patients with uncontrolled thyroid or adrenal dysfunction.

  • What should I tell my doctor before I take the first dose of Serophene?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning therapy with Serophene. Also, talk to your doctor about your complete medical history; this includes any history of liver problems, abnormal uterine bleeding, ovarian cysts, and if you are pregnant or breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual dosage of Serophene begins low, at 50 milligrams (mg) daily (1 tablet) for 5 days. The dose should be increased to 100 mg for 5 days only in women who do not ovulate in response to 50 mg of Serophene.

  • How should I take Serophene?

    Serophene tablets are taken only by mouth.

  • What should I avoid while taking Serophene?

    Avoid activities that require your complete alertness, such as driving a car or operating heavy machinery, as Serophene may cause blurred vision and dizziness.

  • What are possible food and drug interactions associated with Serophene?

    No significant interactions have been reported with Serophene at this time. However, always tell your doctor about any medicines you take, including over-the-counter drugs, vitamins, and herbal supplements.

  • What are the possible side effects of Serophene?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: abnormal uterine bleeding (such as spotting), blind spots, blurred vision, breast pain, double-vision, headache, light sensitivity, sensation of seeing light, stomach and lower-stomach discomfort/pain/bloating, vision problems

    Symptoms of OHSS are: diarrhea, nausea, stomach pain and discomfort, vomiting, weight gain

  • Can I receive Serophene if I am pregnant or breastfeeding?

    Do not take Serophene if you are pregnant, or nursing. This drug may cause severe birth defects in your child. Serophene and may pass into your breast milk.

  • What should I do if I miss a dose of Serophene?

    If you miss a dose of this medication, take it as soon as you remember. If it is time for your next dose, then take the two doses together and go back to your regular dosing schedule. If you miss more than one dose, contact your doctor.

  • How should I store Serophene?

    Store at room temperature, away from heat, light, and excessive humidity.

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I'm Kristen Dore, PharmD. Welcome to PDR Health!

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