Generic Name: Doxepin

  • What is Silenor?

    Silenor is a sleep medicine used to treat insomnia.

  • What is the most important information I should know about Silenor?

    Do not take Silenor if you cannot get a full night of sleep before you must be active again.

    Do not take Silenor within 3 hours of a meal. Silenor may not work as well, or may make you sleepy the next day if taken with or right after a meal.

    Do not take Silenor with alcohol or more Silenor than prescribed. Do not take Silenor if you take other medicines that can make you sleepy. Take Silenor 30 minutes before bedtime.

    After taking Silenor, you should only do activities needed to get ready for bed. After taking Silenor, you may get up out of bed while not being fully awake and do an activity that you do not know you are doing. The next morning, you may not remember that you did anything during the night. You have a higher chance for doing these activities if you drink alcohol or take other medicines that make you sleepy with Silenor. Reported activities include driving a car ("sleep-driving"), making and eating food, talking on the phone, having sex, and sleep-walking. Call your doctor right away if you find out that you have done any of the above activities after taking Silenor.

    Call your doctor if your sleep problems get worse or do not get better within 7-10 days. This may mean that there is another condition causing your sleep problem.

  • Who should not take Silenor?

    Do not take Silenor if you have taken a monoamine oxidase inhibitor (MAOI) within the last 14 days; have an eye problem called narrow-angle glaucoma (high pressure in the eye) that is not being treated; have trouble urinating; or if you are allergic to any of the ingredients in Silenor.

  • What should I tell my doctor before I take the first dose of Silenor?

    Tell your doctor about all prescription, over-the-counter, and herbal medication you are taking before beginning treatment with Silenor. Also, talk to your doctor about your complete medical history, especially if you have a history of glaucoma and are not being treated; have trouble urinating; have a history of depression, mental illness, or suicidal thoughts; have severe sleep apnea (breathing that stops during sleep); have kidney or liver disease; have a history of drug or alcohol abuse or addiction; have a history of urinary retention; are pregnant or plan to become pregnant; or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended dose is 6 milligrams (mg) once daily. In people ≥65 years, your doctor may start you on a 3-mg once daily dose. The total Silenor dose should not exceed 6 mg per day.

  • How should I take Silenor?

    Take Silenor exactly as prescribed by your doctor. Do not take Silenor within 3 hours of a meal. Take Silenor within 30 minutes of bedtime. After taking it, you should confine your activities to those necessary to prepare for bed.

  • What should I avoid while taking Silenor?

    You should not drink alcohol while taking Silenor. Alcohol can increase your chances of getting serious side effects with Silenor.

    You should not drive, operate heavy machinery, or do other dangerous activities after taking Silenor. You may still feel drowsy the next day after taking it. Do not drive or do other dangerous activities after taking Silenor until you feel fully awake.

  • What are possible food and drug interactions associated with Silenor?

    If Silenor is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Silenor with the following: alcohol, certain allergy medicines (antihistamines) or other medicines that can make you sleepy or affect your breathing, cimetidine or other medicines that can affect certain liver enzymes, MAOIs, and tolazamide.

  • What are the possible side effects of Silenor?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: drowsiness or tiredness, nausea, upper respiratory tract infection, high blood pressure

  • Can I receive Silenor if I am pregnant or breastfeeding?

    It is not known if Silenor will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.

    Silenor can pass into breast milk and may harm your baby. You should not breastfeed while taking Silenor.

  • What should I do if I miss a dose of Silenor?

    Contact your doctor if you miss a dose of Silenor.

  • How should I store Silenor?

    Store at room temperature in a tightly closed container, away from light.

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