Simcor

Generic Name: Simvastatin

  • What is this medication and its most common uses?

    Simcor is a medicine used to lower your cholesterol (fats in your blood) when a low-fat diet is not enough. Simcor lowers your total cholesterol, "bad" low-density lipoprotein (LDL) cholesterol, and triglycerides (a type of blood fat), and increases "good" high-density lipoprotein (HDL) cholesterol.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Simcor contains two cholesterol medicines: niacin and simvastatin. Niacin is thought to work by increasing the removal of triglycerides from your blood, and simvastatin blocks a protein in the liver that makes cholesterol. Together, this results in lower levels of cholesterol. By lowering "bad" cholesterol, lowering triglycerides, and by increasing the amount of "good" cholesterol in your blood, Simcor can slow the build-up of fatty deposits in the walls of the arteries in your heart, brain, or other parts of the body.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Along with a low-fat diet, Simcor is proven to lower triglycerides by 27-38% and increase HDL cholesterol by 21-29%, depending on the dose prescribed by your healthcare provider.

    When: Simcor may start working within a few weeks. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

    How do I know it is working?

    Your healthcare provider may do blood tests to check your cholesterol levels during your treatment with Simcor. Appropriate diet and exercise also contribute to your overall heart health and will also affect the results of your blood tests.

    Taking Simcor is not a substitute for following a healthy low-fat and low-cholesterol diet and exercising to lower your cholesterol.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    More common side effects may include: flushing (warm, hot, burning feeling to your face), headache, back pain, diarrhea, nausea, itching.

    Less common side effects may include:

    Muscle problems with symptoms such as unexplained weakness, tenderness, or pain, especially if you also have a fever or feel more tired than usual.

    Liver problems with symptoms such as feeling tired or weak, loss of appetite, upper belly pain, dark-colored urine, or yellowing of your skin or the whites of your eyes.

    Increased blood sugar levels.

  • Who should not take this medication?

    Do not take Simcor if you are allergic to it or any of its ingredients.

    Do not take Simcor if you have liver disease, a stomach ulcer, or bleeding in an artery.

    Do not take Simcor if you are pregnant, plan to become pregnant, or are breastfeeding.

    Do not take Simcor in combination with anti-HIV medications (such as ritonavir), boceprevir, clarithromycin, cyclosporine, danazol, diltiazem, erythromycin, gemfibrozil, itraconazole, ketoconazole, nefazodone, posaconazole, telaprevir, telithromycin, verapamil, or voriconazole.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Simcor. Also, talk to your healthcare provider about your complete medical history, especially if you have muscle aches or weakness; diabetes; gout (severe and painful inflammation of the joints); drink excessive amounts of alcohol; have liver, kidney, or thyroid problems; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: The usual starting dose is 500/20 (500 milligrams [mg] of niacin and 20 mg of simvastatin) once a day. Your healthcare provider may check your blood cholesterol levels during treatment with Simcor and may change your dose based on the results.

    If you have kidney impairment or are taking other medications, your healthcare provider may adjust your dose appropriately.

  • How should I take this medication?

    Take Simcor exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Simcor without first talking to your healthcare provider.

    Take Simcor at bedtime with a low-fat snack.

    Swallow Simcor tablets whole. Do not crush, chew, or break them.

    If you take other cholesterol-lowering medicines known as bile acid resins (such as cholestyramine or colestipol), take Simcor at least 4-6 hours before or after you take the bile acid resin.

    If you stop taking Simcor for more than 7 days, contact your healthcare provider before you start taking it again.

    Your healthcare provider will likely start you on a low-fat diet before prescribing Simcor. Stay on this diet while you are taking Simcor.

  • What should I avoid while taking this medication?

    Do not become pregnant or breastfeed while you are taking Simcor.

    Do not drink large amounts of grapefruit juice (>1 quart per day) while you are taking Simcor.

    Do not drink alcohol or hot drinks, or eat spicy foods around the time you take Simcor to minimize flushing.

  • What are the possible food and drug interactions associated with this medication?

    If Simcor is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Simcor may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

  • May I receive this medication if I am pregnant or breastfeeding?

    Do not take Simcor during pregnancy or breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Simcor, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature.

Starting a Cholesterol Drug?

Our seven-week newsletter series, written by a pharmacist, will help you learn about your medication.
Sign Up

Meet the Pharmacists

I'm Beth Isaac, PharmD. Welcome to PDR Health!

Check out my latest post on cholesterol drugs.

Simcor Related Drugs