What is Soliris?Soliris is a medicine called a monoclonal antibody. Soliris is used for the treatment of patients with a disease that affects the red blood cells called paroxysmal nocturnal hemoglobinuria (PNH).
What is the most important information I should know about Soliris?Soliris can affect your immune system and lower your ability to fight infections. Therefore, it is very important that you have all recommended immunizations before you start treatment with Soliris and stay up-to-date with immunizations during treatment.
Soliris increases your chance of getting serious and life-threatening meningococcal infections. You must receive a meningococcal vaccine at least 2 weeks before your first dose of Soliris unless you have already had this vaccine, in which case you might need a booster dose before starting Soliris. Your doctor will decide if you need another dose of this vaccine.
A meningococcal vaccine does not prevent all meningococcal infections. You must be aware of the following signs and symptoms of a meningococcal infection: confusion; fever of ≥103°F; moderate-to-severe headache associated with nausea or vomiting, fever, or with a stiff neck or back; fever and a rash; severe muscle aches with flu-like symptoms; and eye sensitivity to light. Call your doctor or get emergency medical care right away if you have any of these symptoms.
Stopping treatment with Soliris may cause a sudden and serious breakdown of your red blood cells. Symptoms or problems from red blood cell breakdown include: confusion, chest pain, kidney problems, and blood clots. Your doctor will monitor you closely for at least 8 weeks after stopping Soliris.
Who should not take Soliris?You should not take Soliris if you have a meningococcal infection, or if you have not been vaccinated with, or you are not up-to-date with a meningococcal vaccine.
What should I tell my doctor before I take the first dose of Soliris?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Soliris. Also, talk to your doctor about your complete medical history, especially if you have an infection or fever. Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: Your doctor will determine the appropriate dosage for you.
How should I take Soliris?Your doctor will administer this medication for you via an IV infusion. You will usually receive a Soliris infusion every 7 days for 5 weeks, then every 14 days. Following each infusion, you may be monitored for 1 hour for possible allergic reactions.
What should I avoid while taking Soliris?Avoid situations that increase your exposure to infections, since Soliris weakens your immune system.
What are possible food and drug interactions associated with Soliris?No significant interactions have been reported with Soliris at this time. However, always tell your doctor about any medicines you take, including over-the-counter drugs, vitamins, and herbal supplements.
What are the possible side effects of Soliris?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: headache, runny nose and cold, sore throat, back pain, nausea
Can I receive Soliris if I am pregnant or breastfeeding?The effects of Soliris during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Soliris?If you miss an appointment for your Soliris infusion, call your doctor right away.
How should I store Soliris?Your doctor will store this medication for you.
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