Sprix

Generic Name: Ketorolac

  • What is this medication and its most common uses?

    Sprix is a nonsteroidal anti-inflammatory drug (NSAID) used for the short-term (up to 5 days) treatment of pain. Sprix is available as a nasal spray.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Sprix relieves pain by blocking a substance in your body that is involved in causing inflammation and pain.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Sprix has been shown to reduce pain intensity.

    When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you use Sprix exactly as your healthcare provider has prescribed.

    How do I know it is working?

    You may feel an improvement in your pain after you start using Sprix. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Do not use Sprix for more than 5 days in a row. If you are still experiencing pain after 5 days, contact your healthcare provider.

    Do not use Sprix in children or for minor or long-term pain.

    Sprix may increase the chance of a life-threatening heart attack or stroke. The risk of heart attack or stroke may be increased with longer use and in people who have heart disease. Call your healthcare provider right away if you develop chest pain, shortness of breath, weakness, or slurring of your speech while using Sprix.

    Sprix should never be used right before or after a heart surgery called a coronary artery bypass graft (CABG).

    Sprix can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can be life-threatening and may happen without warning symptoms. The chance of a person getting an ulcer or bleeding increases with longer use, smoking, drinking alcohol, older age, having poor health, and if you are taking medicines called corticosteroids (such as prednisone) or blood thinners (such as warfarin). Call your healthcare provider right away if you develop stomach pain, indigestion, bloody or tarry stools, or you vomit blood while using Sprix.

    Sprix can also cause other bleeding problems. Tell your healthcare provider if you have any type of bleeding disorder before you start using Sprix.

    Sprix can cause kidney problems. Tell your healthcare provider if you have any kidney problem before you start using Sprix.

    More common side effects may include: nasal discomfort or pain, increased tearing, throat irritation, low urine output, rash, slow heart rate, high blood pressure, runny and stuffy nose.

    Less common side effects may include:

    Liver problems with symptoms such as nausea, tiredness, weakness, itching, yellowing of your skin or the whites of your eyes, right upper stomach pain, and flu-like symptoms.

    Serious allergic reactions with symptoms such as skin rash, blisters, fever, itching, trouble breathing, or swelling of your face or throat.

    Sprix may cause unexplained weight gain or swelling.

    Sprix can harm your unborn baby if you use it during the late stages of your pregnancy (>30 weeks). Talk to your healthcare provider about other treatment options if you plan to become pregnant. Tell your healthcare provider right away if you become pregnant while using Sprix.

  • Who should not take this medication?

    Do not use Sprix if you are allergic to it or any of its ingredients.

    Do not use Sprix if you are allergic to, or have had an asthma attack, hives, or other allergic reactions with aspirin or other NSAIDs (such as ibuprofen or naproxen).

    Do not use Sprix for pain right before or after heart bypass surgery.

    Do not use Sprix before any major surgery or during labor and delivery.

    Do not use Sprix if you have kidney disease.

    Do not use Sprix if you are breastfeeding.

    Do not use Sprix if you have or have had a history of an ulcer or bleeding in your stomach or intestines.

    Do not use Sprix if you have certain other bleeding problems.

    Do not use Sprix if you are currently taking probenecid or pentoxifylline.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Sprix. Also, talk to your healthcare provider about your complete medical history, especially if you have asthma; high blood pressure; heart failure; kidney or liver problems; a history of ulcers or bleeding in your stomach or intestines; other bleeding problems; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: The recommended dose is one spray in each nostril every 6 to 8 hours. Do not use more than 4 doses of Sprix in one day.

    If you are elderly, have kidney problems, or weigh <110 pounds, your healthcare provider may recommend a lower dose.

  • How should I take this medication?

    Use Sprix exactly as prescribed by your healthcare provider. Do not change your dose without first talking to your healthcare provider.

    Each bottle contains 1 day's supply of pain medicine. Do not use any single bottle for more than one day. Discard the bottle within 24 hours after taking the first dose, even if the bottle still contains some unused medicine.

    Drink plenty of fluids while you are using Sprix.

    Do not use Sprix for longer than 5 days in a row. If you are still experiencing pain after 5 days, call your healthcare provider.

    Please review the instructions that came with your prescription on how to use your spray properly.

  • What should I avoid while taking this medication?

    Do not spray Sprix into your eyes. If eye contact occurs, wash out your eye with water or saline, and contact your healthcare provider if irritation lasts for more than an hour.

  • What are the possible food and drug interactions associated with this medication?

    If Sprix is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Sprix with the following: alprazolam, antidepressant medications known as selective serotonin reuptake inhibitors or "SSRIs" (such as citalopram or sertraline), aspirin, certain blood pressure/heart medications (such as lisinopril or valsartan), fluoxetine, lithium, methotrexate, pentoxifylline, probenecid, seizure medicines (such as phenytoin or carbamazepine), thiothixene, warfarin, or water pills (such as furosemide or hydrochlorothiazide).

  • May I receive this medication if I am pregnant or breastfeeding?

    Sprix can harm your unborn baby if you use it during the late stage of your pregnancy (≥30 weeks). The effects of Sprix during early pregnancy are unknown. Sprix can be found in your breast milk if you use it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Sprix, use it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not use two doses at once.

  • How should I store this medication?

    Store at room temperature. Protect from light and freezing.

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