Sprycel

Generic Name: Dasatinib

  • What is Sprycel?

    Sprycel is a prescription medicine used to treat adults who have chronic myeloid leukemia (CML) and also to treat adults who have a form of acute lymphoblastic leukemia (ALL) called Philadelphia chromosome positive (Ph+ ALL). It is mostly used for treatment of these conditions when other therapies have failed.
  • What is the most important information I should know about Sprycel?

    Sprycel should not be used during pregnancy. Women should avoid becoming pregnant during treatment; if you do become pregnant, tell your doctor immediately.
  • Who should not take Sprycel?

    Do not begin treatment with Sprycel unless you have already been treated with Gleevec and it failed.

    If you are pregnant do not begin treatment with this drug. Also, do not use Sprycel if you are allergic to any of its ingredients.

  • What should I tell my doctor before I take the first dose of Sprycel?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning therapy with Sprycel. Talk to your doctor about your complete medical history, especially if you have a liver or heart problem, or you are lactose intolerant. If you are pregnant, planning to become pregnant, or are nursing, tell your doctor. If you are a sexually active male, you should use a condom during intercourse to prevent pregnancy.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    The recommended dosage of Sprycel is 140 milligrams (mg) a day administered orally in two divided doses (70 mg twice daily), one in the morning and one in the evening.

  • How should I take Sprycel?

    Sprycel can be taken with or without a meal. Tablets should be swallowed whole; do not crush, chew, or cut Sprycel tablets.
  • What should I avoid while taking Sprycel?

    Avoid pregnancy and breastfeeding during therapy with Sprycel.

    Do not crush, chew, or cut Sprycel tablets.

  • What are possible food and drug interactions associated with Sprycel?

    If Sprycel is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Sprycel with the following:

    Medicines that increase the amount of Sprycel in your bloodstream:

    Biaxin (clarithromycin), Crixivan (indinavir), E-mycin (erythromycin), Invirase (saquinavir), Ketek (telithromycin), Norvir (ritonavir), Nizoral (ketoconazole), Reyataz (atazanavir sulfate), Sporanox (itraconazole), Viracept (nelfinavir)

    Medicines that decrease the amount of Sprycel in your bloodstream:

    Decadron (dexamethasone), Dilantin (phenytoin), Luminal (phenobarbital), Rimactane (rifampicin), Tegretol (carbamazepine)

    Medicines whose blood levels might be altered by Sprycel: Alfenta (alfentanil), Ergomar (ergotamine), Fentanyl (fentanyl), Orap (pimozide), Prograf (tacrolimus), Rapamune (sirolimus), Sandimmune (cyclosporine)

  • What are the possible side effects of Sprycel?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: diarrhea, fatigue, headache, nausea, skin rash

    Notify your doctor immediately if you have: bleeding/easy bruising, fever, weight gain/fluid retention

  • Can I receive Sprycel if I am pregnant or breastfeeding?

    Do not begin treatment with Sprycel if you are pregnant, planning to become pregnant, or are nursing. This drug may pass into breast milk. If you are a sexually active male, use a condom during intercourse to prevent pregnancy.
  • What should I do if I miss a dose of Sprycel?

    If you miss a dose of Sprycel, take your next scheduled dose at its regular time. Do not take two doses at the same time.
  • How should I store Sprycel?

    Store at room temperature.