What is Supprelin LA?Supprelin LA is a subcutaneous (under-the-skin) implant that contains the medicine histrelin, which blocks the action of the gonadotropin-releasing hormone (GnRH). Supprelin LA is used to treat children with central precocious puberty (CPP), which triggers early onset of puberty in girls (<8 years old) and in boys (<9 years old). Signs of early puberty include breast enlargement in girls and the appearance of hair in the genital area in boys and girls. Supprelin LA reduces the amount of sex hormones in the blood to delay early puberty.
What is the most important information I should know about Supprelin LA?Make sure the diagnosis of CPP is confirmed by tests before beginning treatment.
Supprelin LA should not be used if the patient is pregnant or becomes pregnant, because it may cause harm to the fetus.
During the first few weeks of treatment, Supprelin LA can cause a brief increase in some hormones, and during this time you may notice more signs of puberty, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs that puberty is stopping.
Hormone levels should be measured by your child's doctor 1 month after implantation, and every 6 months after. Height and bone age should also be measured by your child's doctor every 6-12 months.
Who should not take Supprelin LA?Do not use Supprelin LA if you are allergic to GnRH, GnRH agonist medicines, or anything in the Supprelin LA implant. Supprelin LA should not be used in children <2 years old or in women who are or may become pregnant (Supprelin LA can cause birth defects or loss of the baby).
What should I tell my doctor before I take the first dose of Supprelin LA?Tell your doctor about all prescription, over-the-counter, and herbal medications your child is taking before beginning treatment with Supprelin LA. Also, talk to your doctor about your child's complete medical history, especially if she is pregnant. Make sure to mention any allergies to medications.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Children >2 years: The recommended dose of Supprelin LA is one 50-milligram (mg) implant every 12 months. The drug is slowly released at a rate of about 65 micrograms (mcg) a day.
How should I take Supprelin LA?Your doctor will implant Supprelin LA. The implant must be removed after about 12 months of therapy, at which time another implant can be inserted or the physician may choose to discontinue the treatment.
Supprelin LA is placed under the skin of the inside of the upper arm. The doctor will temporarily numb the arm, make a small cut, and then place Supprelin LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage.
Keep the arm clean and dry. Do not swim or bathe for 24 hours. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in several days.
What should I avoid while taking Supprelin LA?Avoid heavy play or exercise that affects the implanted arm for 7 days. After the cut has healed, you can go back to normal activities. The doctor will give you complete instructions.
What are possible food and drug interactions associated with Supprelin LA?No formal drug-drug, drug-food, or drug-herb interactions studies were performed with Supprelin LA.
What are the possible side effects of Supprelin LA?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: implant-site reactions (such as bruising, soreness, pain, tingling, itching, swelling), a brief increase in some hormone levels, allergic reactions
Can I receive Supprelin LA if I am pregnant or breastfeeding?You should not take this medication if you are pregnant or may become pregnant. It may cause harm to the fetus.
The effects of using Supprelin LA if you are breastfeeding are unknown.
What should I do if I miss a dose of Supprelin LA?Since this medication is implanted in a doctor's office once every 12 months, there is no dosing schedule to follow.
How should I store Supprelin LA?Supprelin LA is only administered in a doctor's office.
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