Generic Name: Peginterferon alfa-2b

  • What is Sylatron?

    Sylatron is a medicine used to prevent malignant melanoma (a type of skin cancer) from coming back after it has been removed by surgery. Sylatron is administered subcutaneously (injection under the skin).

  • What is the most important information I should know about Sylatron?

    Sylatron can cause serious mental health problems which can lead to suicide. Signs and symptoms can include depression, aggressive behavior towards others, thoughts of hurting others, memory changes, or confusion.

    Sylatron can also cause other serious side effects or worsen existing conditions, including heart problems (such as fast heart rate, abnormal heart rate, trouble breathing, or chest pain), eye problems (such as blurred or decreased vision), liver problems (such as yellowing of your skin or the whites of your eyes, or swelling of your stomach area), thyroid problems (such as problems concentrating, feeling cold or hot all of the time, or weight changes), or high blood sugar (diabetes). Contact your doctor if you have any of these signs or if they get worse.

    Your doctor will perform blood tests before starting, and during your treatment with Sylatron. It is important for you to keep all appointments with your doctor.

  • Who should not take Sylatron?

    Do not use Sylatron if you are allergic to it or any of its ingredients, if you have certain types of hepatitis, or if you have severe liver damage.

  • What should I tell my doctor before I take the first dose of Sylatron?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Sylatron. Also, talk to your doctor about your complete medical history, especially if you are being treated for a mental health illness or had treatment in the past for a mental illness, including depression or thoughts of suicide or suicide attempts; have diabetes; have severe liver, thyroid, or eye problems; have any other medical conditions; or are pregnant, plan to become pregnant, are breastfeeding, or plan to breastfeed.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Your doctor will prescribe the appropriate dose for you based on your weight.

    If you have kidney impairment, your doctor will adjust your dose appropriately.

  • How should I take Sylatron?

    Inject Sylatron exactly as prescribed by your doctor.

    Sylatron is given as a subcutaneous injection. Your doctor will show you how to prepare and measure your dose of Sylatron, and how to inject yourself before you use Sylatron for the first time.

    Do not inject more than your prescribed dose. Call your doctor immediately if you inject too much Sylatron.

    Inject Sylatron one time each week at bedtime, unless your doctor gives you a different instruction.

    To help reduce "flu-like" symptoms, take 500-1000 milligrams (mg) of acetaminophen 30 minutes before your first dose of Sylatron. Follow your doctor's instructions about taking acetaminophen before future doses of Sylatron.

  • What should I avoid while taking Sylatron?

    Do not breastfeed while you are using Sylatron.

  • What are possible food and drug interactions associated with Sylatron?

    If Sylatron is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is important to check with your doctor before combining Sylatron with any other medication.

  • What are the possible side effects of Sylatron?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: changes in blood tests measuring how your liver works, chills, feeling sad or depressed, fever, headaches, itching around the injection site, joint or muscle aches, loss of appetite, nausea, redness or swelling around the injection site, tiredness

  • Can I receive Sylatron if I am pregnant or breastfeeding?

    The effects of Sylatron during pregnancy are unknown. Do not use Sylatron while you are breastfeeding. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Sylatron?

    Sylatron should be given under special circumstances determined by your doctor. If you miss your scheduled dose, contact your doctor or pharmacist for advice.

  • How should I store Sylatron?

    Store at room temperature before mixing. After mixing, use it right away or refrigerate it for up to 24 hours. Do not freeze.