Generic Name: Verapamil

  • What is this medication and its most common uses?

    Tarka is a medicine used to treat high blood pressure. Tarka contains two medicines that work in two different ways to reduce your blood pressure: trandolapril and verapamil.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Tarka is an extended-release medicine, which releases medicine into your body throughout the day. Tarka works by blocking a chemical in your body that causes blood vessels to narrow. By blocking this chemical, Tarka relaxes and widens your blood vessels, allowing your blood to flow through with less resistance. This helps to lower your blood pressure.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: By lowering your blood pressure, Tarka may lower your risk of a stroke or a heart attack.

    When: Tarka may start lowering your blood pressure within 1 week. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

    How do I know it is working?

    Check your blood pressure regularly. Your healthcare provider may also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Tarka can harm your unborn baby. Talk to your healthcare provider about other ways to lower your blood pressure if you plan to become pregnant. Tell your healthcare provider right away if you become pregnant while taking Tarka.

    More common side effects may include: headache, upper respiratory infection, cough, constipation, dizziness.

    Less common side effects may include:

    Risk of having a very slow heart rate, congestive heart failure (a condition in which your heart cannot pump enough blood throughout your body), low blood pressure, or liver injury.

    Serious allergic reactions with symptoms such as extreme swelling of your face, lips, tongue, or throat.

    Low blood neutrophil (type of blood cells that fight infections) levels with symptoms of an infection (such as sore throat or fever).

  • Who should not take this medication?

    Do not take Tarka if you are allergic to it, any of its ingredients, or if you have a history of angioedema related to previous treatment with similar medicines.

    Do not take Tarka if you have severe left ventricular dysfunction (impairment of a section of your heart that is responsible for pumping blood to the rest of your body).

    Do not take Tarka if you have low blood pressure.

    Do not take Tarka if you have sick sinus syndrome (abnormal heart rhythm) or a heart block, unless you have a pacemaker.

    Do not take Tarka if you have atrial fibrillation or flutter (an irregular, fast heartbeat) and certain heart conduction problems (such as Wolff-Parkinson-White or Lown-Ganong-Levine syndrome).

    Do not take Tarka if you have diabetes and are taking another blood pressure medicine called aliskiren.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Tarka. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes; heart, kidney, or liver problems; cough; a disease that affects your immune system (such as lupus); low blood pressure; certain conditions that cause muscle weakness (such as myasthenia gravis or Duchenne's muscular dystrophy); a history of angioedema; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    Also, talk to your healthcare provider about any planned surgeries or procedures.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: Your healthcare provider will prescribe the appropriate dose for you based on your previous blood pressure medication, and may increase your dose as needed, until the desired effect is achieved.

    If you have liver impairment, your healthcare provider may adjust your dose appropriately.

  • How should I take this medication?

    Take Tarka exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Tarka without first talking to your healthcare provider.

    Take Tarka with food.

  • What should I avoid while taking this medication?

    Do not become pregnant while taking this medication.

  • What are the possible food and drug interactions associated with this medication?

    If Tarka is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Tarka with the following: almotriptan, blood pressure/heart medications (such as prazosin, metoprolol, or losartan), buspirone, carbamazepine, cholesterol-lowering medications known as statins (such as lovastatin or simvastatin), clarithromycin, colchicine, cyclosporine, diabetes medicines (such as insulin or glyburide), digoxin, disopyramide, doxorubicin, erythromycin, flecainide, glyburide, imipramine, lithium, midazolam, nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen or naproxen), phenobarbital, potassium supplements, quinidine, rifampin, ritonavir, salt substitutes containing potassium, sirolimus, tacrolimus, telithromycin, theophylline, or water pills (such as spironolactone or furosemide).

  • May I receive this medication if I am pregnant or breastfeeding?

    Do not take Tarka if you are pregnant or breastfeeding. Tarka may harm your unborn baby. Tarka can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Tarka, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature.

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