What is Tasigna?Tasigna is used treat the chronic phase and accelerated phase of Philadelphia chromosome-positive chronic myelogeneous leukemia (CML) in patients resistant to previous therapy.
What is the most important information I should know about Tasigna?Tasigna can cause QT prolongation (irregular heart beat) and sudden death. It can also suppress the bone marrow, hence reducing the body's ability to fight infections, and may cause anemia and bleeding.
Who should not take Tasigna?Do not take Tasigna if you have low potassium or low magnesium levels.
What should I tell my doctor before I take the first dose of Tasigna?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Tasigna. Also talk to your doctor about your complete medical history, especially if you had a history of heart problems (including irregular heartbeat or QTc prolongation), liver problems, pancreatitis, low blood levels of potassium or magnesium, or a severe problem with lactose or other blood sugars.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: The usual dosage of Tasigna is 400 milligrams (mg) twice daily.
How should I take Tasigna?Take Tasigna twice a day, 12 hours apart.
Do not take Tasigna with food. Take Tasigna at least 2 after eating and then wait at least 1 hour before eating again.
What should I avoid while taking Tasigna?Do not open Tasigna capsules. Do not drink grapefruit juice, eat grapefruit, or take any supplements containing grapefruit extract.
What are possible food and drug interactions associated with Tasigna?If Tasigna is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Tasigna with the following: ketoconazole, rifampicin, or any drug that prolongs QTc (check with your doctor or pharmacist).
What are the possible side effects of Tasigna?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: irregular heartbeat, liver damage, fluid retention, inflammation of the pancreas, rash, nausea, headache, itching, diarrhea, constipation
Can I receive Tasigna if I am pregnant or breastfeeding?Avoid Tasigna during pregnancy and breastfeeding.
What should I do if I miss a dose of Tasigna?If you miss a dose, take your next dose as scheduled. Do not take 2 doses at once.
How should I store Tasigna?Store at room temperature.