Generic Name: Tolcapone

  • What is Tasmar?

    Tasmar is used together with a carbidopa/levodopa combination to treat Parkinson's disease. Tasmar helps to relieve the muscle stiffness, tremors, and weakness caused by Parkinson's disease.
  • What is the most important information I should know about Tasmar?

    In rare cases, Tasmar has caused severe liver damage resulting in death. Tell your doctor immediately if you develop abdominal pain, clay colored stools, dark urine, itching, loss of appetite, nausea, unusual fatigue, vomiting, or yellow skin or eyes. These symptoms may be early signs of liver damage. Your doctor will want to monitor your liver function with blood tests.

    Due to the risk of severe liver damage, Tasmar should only be used in combination with carbidopa/levodopa if you are not responding adequately to carbidopa/levodopa alone and cannot take other medicines for this condition.

  • Who should not take Tasmar?

    Do not take Tasmar if you have liver disease or if you previously took Tasmar but had to stop therapy due to liver injury. Avoid Tasmar if you are allergic to it, or if you experience unexplained muscle tenderness or pain, high fever, or confusion.
  • What should I tell my doctor before I take the first dose of Tasmar?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Tasmar. Also, talk to your doctor about your complete medical history, especially if you have kidney or liver disease, are taking monoamine oxidase inhibitors (MAOIs) such as phenelzine and tranylcypromine, or have a history of rhabdomyolysis.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual dose is 100 milligrams (mg) 3 times a day (every 6 hours) in combination with carbidopa and levodopa.

    Your doctor may increase your dose to 200 mg 3 times a day if necessary. If you do not benefit from the higher dose after 3 weeks of treatment, your doctor will stop therapy with Tasmar.

  • How should I take Tasmar?

    Tasmar works by increasing the efficacy of carbidopa/levodopa, and will not work without it. It can be taken with either the immediate-release or controlled-release form of levodopa/carbidopa, with or without food.

    Always take the first dose of Tasmar with your first dose of levodopa/carbidopa. Take your second and third doses of Tasmar 6 and 12 hours later. Your doctor will probably decrease your dose of levodopa/carbidopa when you start taking Tasmar.

  • What should I avoid while taking Tasmar?

    Tasmar can cause drowsiness and affect mental and motor skills. Avoid operating machinery, driving, and performing other activities that require mental alertness until you know how the drug affects you.

    Tasmar can cause severe low blood pressure marked by nausea, sweating, dizziness, or fainting. This usually occurs at the start of therapy. To avoid these symptoms, get up very slowly from a seated or reclining position.

    Avoid drinking alcohol while taking Tasmar. Alcohol may increase drowsiness and dizziness.

  • What are possible food and drug interactions associated with Tasmar?

    If Tasmar is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Tasmar with the following: apomorphine, desipramine, dobutamine, isoproterenol, MAO inhibitors (such as phenelzine and tranylcypromine), methyldopa, sedatives (such as phenobarbital and secobarbital), warfarin.
  • What are the possible side effects of Tasmar?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: abnormal jerky movements, diarrhea, dizziness or fainting, hallucinations, sleep disorders

    Serious side effects may include: confusion, death, extremely high fever, unexplained muscle tenderness or pain (rhabdomyolysis)

    Tell your doctor if you experience persistent nausea, fatigue, loss of appetite, yellowing of the skin or eyes, dark urine, itchiness, and right-sided abdominal pain. Your doctor should do a blood test to check your liver function before you start Tasmar therapy, then every 2 weeks for the first year, every 4 weeks for the next 6 months, and every 8 weeks thereafter.

    Hallucinations are most likely to occur within the first 2 weeks of therapy. If this problem occurs, tell your doctor right away.

  • Can I receive Tasmar if I am pregnant or breastfeeding?

  • What should I do if I miss a dose of Tasmar?

    Take it as soon as you remember. If it is almost time for your next dose (within 3 hours), skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.
  • How should I store Tasmar?

    Store at room temperature in a tightly sealed container.