Ticlopidine

Generic Name: Ticlopidine

  • What is this medication and its most common uses?

    Ticlopidine is a medicine used to help reduce the risk of stroke in people who have had a stroke or early stroke warning symptoms while being treated with aspirin, or for those who are intolerant or allergic to aspirin. Ticlopidine is also used in combination with aspirin for up to 30 days to reduce the risk of blood clots in stents placed in the heart to open blocked arteries.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    A stroke happens when a clot forms in a blood vessel in the brain or forms in another part of the body and breaks off, then travels to the brain. In both cases, the blood supply to part of the brain is blocked and that part of the brain is damaged. A heart attack or chest pain can happen when fatty deposits block the arteries that carry blood, oxygen, and nutrients to your heart. In this case, your healthcare provider may recommend the placement of a stent in your heart to decrease the chance of fatty deposits building up over time. Ticlopidine works by making platelets in the blood less sticky, so they are less likely to clump together and form blood clots.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Ticlopidine has been shown to reduce your risk of having a stroke or blood clots in your stent.

    When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take ticlopidine exactly as your healthcare provider has prescribed.

    How do I know it is working?

    Your healthcare provider will monitor you regularly to check how well this medication is working.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Ticlopidine can cause a condition known as neutropenia (a decrease in the number of white blood cells that fight infection). Tell your healthcare provider immediately if you develop any signs of infection, including fever, chills, or sore throat.

    Ticlopidine can cause thrombotic thrombocytopenic purpura (TTP) (a condition in which blood clots form in the blood vessels and can occur all over the body). Tell your healthcare provider immediately if you develop yellowing of your skin or the whites of your eyes, pinpoint dots on your skin, paleness, fever, weakness on a side of the body, or dark urine.

    Rarely, ticlopidine can cause a condition known as aplastic anemia (a blood disorder in which the body's bone marrow doesn't make enough new blood cells). Tell your healthcare provider immediately if you develop excessive weakness and tiredness, paleness, bruising, or bleeding (such as from your nose or gums), or signs of an infection (such as fever).

    These life-threatening blood problems occur most frequently during the first 3 months of treatment. Your healthcare provider will arrange for you to have blood tests before you start taking ticlopidine and then every 2 weeks for the first 3 months you are taking ticlopidine. If you stop taking ticlopidine for any reason within the first 3 months, you still need to have your blood tested for an additional 2 weeks after you stop taking ticlopidine.

    More common side effects may include: diarrhea, nausea, indigestion, rash, stomach pain.

    Less common side effects may include:

    Increased cholesterol (fats in your blood) and triglyceride (type of fat in the blood) levels.

    Longer time to stop bleeding than usual. Tell your healthcare provider if you have any more bleeding or bruising than usual.

  • Who should not take this medication?

    Do not take ticlopidine if you are allergic to it or any of its ingredients.

    Do not take ticlopidine if you have blood disorders (such as neutropenia or low platelet levels, or a history of TTP or aplastic anemia).

    Do not take ticlopidine if you have a serious bleeding problem (such as a bleeding stomach ulcer).

    Do not take ticlopidine if you have severe liver disease.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with ticlopidine. Also, talk to your healthcare provider about your complete medical history, especially if you have any bleeding, liver, or kidney problems; stomach ulcers; are planning to have surgery or a dental procedure; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: The recommended dose is 250 milligrams twice a day.

    If you have kidney or liver impairment, your healthcare provider may adjust your dose appropriately.

  • How should I take this medication?

    Take ticlopidine exactly as prescribed by your healthcare provider. Do not change your dose or stop taking ticlopidine without first talking to your healthcare provider.

    Take ticlopidine with food or just after eating in order to minimize stomach discomfort.

  • What should I avoid while taking this medication?

    Do not miss any scheduled follow-up appointments or blood tests with your healthcare provider.

  • What are the possible food and drug interactions associated with this medication?

    If ticlopidine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining ticlopidine with the following: antacids, aspirin, blood thinners (such as warfarin), cimetidine, digoxin, nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen or naproxen), phenytoin, propranolol, or theophylline.

  • May I receive this medication if I am pregnant or breastfeeding?

    The effects of ticlopidine during pregnancy and breastfeeding are unknown. Do not breastfeed while taking ticlopidine. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of ticlopidine, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature. Protect from light.