Generic Name: Dofetilide

  • What is Tikosyn?

    Tikosyn is a medicine used to treat or prevent atrial fibrillation/flutter (irregular heartbeats). Tikosyn may help your heart continue beating regularly for a longer period of time.

  • What is the most important information I should know about Tikosyn?

    Tikosyn can cause a different type of abnormal heartbeat (called ventricular arrhythmia); which can be dangerous and life-threatening. Therefore, treatment with Tikosyn must be started in a hospital where your heart rate and kidney function will be checked for the first 3 days of treatment.

    Tell your doctor and go to the hospital immediately if you feel faint, become dizzy, or have a fast heartbeat.

  • Who should not take Tikosyn?

    Do not take Tikosyn if you are allergic to it, any of its ingredients, or if you have an irregular heartbeat called long QT syndrome or severe kidney impairment. Also, do not take Tikosyn if you are taking cimetidine, hydrochlorothiazide, ketoconazole, megestrol, prochlorperazine, trimethoprim, or verapamil.

  • What should I tell my doctor before I take the first dose of Tikosyn?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Tikosyn. Also, talk to your doctor about your complete medical history, especially if you have certain heart problems, kidney or liver disease, or low blood potassium or magnesium levels.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Your doctor will prescribe the appropriate dose for you based on your condition.

    If you have kidney impairment, your doctor will adjust your dose appropriately.

  • How should I take Tikosyn?

    Take Tikosyn exactly as prescribed by your doctor. Your doctor will monitor you with an electrocardiogram for at least the first 3 days of treatment. This will allow your doctor to find the right dose for you. You can take Tikosyn with or without food.

  • What should I avoid while taking Tikosyn?

    Do not change your Tikosyn dose unless your doctor tells you to. Do not stop taking Tikosyn until your doctor tells you to stop.

  • What are possible food and drug interactions associated with Tikosyn?

    If Tikosyn is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Tikosyn with the following: certain medicines that can cause other dangerous abnormal heartbeats (such as amitriptyline, chlorpromazine, cisapride, erythromycin, or moxifloxacin), cimetidine, diuretics (water pills) (such as hydrochlorothiazide), ketoconazole, megestrol, other antiarrhythmics (such as amiodarone, disopyramide, procainamide, quinidine, or sotalol), prochlorperazine, trimethoprim, or verapamil.

  • What are the possible side effects of Tikosyn?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: abdominal pain, chest pain, diarrhea, dizziness, headache, increased thirst, loss of appetite, nausea, rash, shortness of breath, sweating, vomiting

  • Can I receive Tikosyn if I am pregnant or breastfeeding?

    The effects of Tikosyn during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Tikosyn?

    If you miss a dose of Tikosyn, skip the one you missed and return to your regular dosing schedule. Do not try to make up for a missed dose. Do not take two doses at once.

  • How should I store Tikosyn?

    Store at room temperature. Keep in a tightly closed container and away from moisture and humidity.