Generic Name: Tolazamide

  • What is Tolazamide?

    Tolazamide is used to lower blood glucose (sugar) levels in people with type 2 diabetes, along with diet and exercise.

  • What is the most important information I should know about Tolazamide?

    Always remember that tolazamide is an aid to helping to control your glucose (sugar) levels. It is not a substitute for a good diet and exercise.

    Taking tolazamide may increase your risk of developing heart problems.

    Tolazamide may cause severe lowering of blood sugar (hypoglycemia). There is a greater risk of hypoglycemia if you have kidney or liver problems; are elderly, debilitated, or malnourished; have adrenal or pituitary problems; don't eat enough; exercise too much; drink alcohol; or use multiple diabetes medications.

    Loss of blood sugar control may occur when you are exposed to stress such as trauma, fever, infection, or surgery. Insulin may be necessary.

    Tolazamide may cause hemolytic anemia (a destruction of red blood cells) in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

    If you are taking tolazamide, you should check your blood or urine periodically for abnormal glucose levels.

  • Who should not take Tolazamide?

    Do not take tolazamide if you are allergic to any of its ingredients.

    Tolazamide should not be taken if you are suffering from diabetic ketoacidosis (a life-threatening medical emergency caused by insufficient insulin and marked by excessive thirst, nausea, fatigue, pain below the breastbone, and fruity breath).

    In addition, tolazamide should not be used as sole therapy in treating type 1 diabetes.

  • What should I tell my doctor before I take the first dose of Tolazamide?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with tolazamide. Also, talk to your doctor about your complete medical history, especially if you have kidney disease, liver disease, thyroid disease, G6PD deficiency, type 1 diabetes, diabetic ketoacidosis, heart problems, a serious infection, illness, injury, or need surgery.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual starting dose for mild to moderately severe type 2 diabetes is 100-250 milligrams (mg) daily, taken with breakfast or the first main meal. If you are malnourished, underweight, older, or not eating properly, the initial dose is usually 100 mg daily.

    The usual maintenance dose is 100-1,000 mg daily. Your doctor may adjust your dosage by 100-250 mg at weekly intervals based on your blood sugar response.

  • How should I take Tolazamide?

    Take tolazamide exactly as prescribed, once a day with breakfast or the first main meal. Doses of more than 500 mg daily may be divided and taken twice daily.

    Failure to follow an appropriate dosage regimen may cause hypoglycemia. If you do not follow your prescribed dietary regimen, you are more likely to have a poor response to this medication.

  • What should I avoid while taking Tolazamide?

    Avoid alcohol, which lowers blood sugar and may interfere with your diabetes treatment.

  • What are possible food and drug interactions associated with Tolazamide?

    If tolazamide is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining it with the following: alcohol, beta-adrenergic blocking agents (such as propranolol and metoprolol), calcium channel blockers (such as verapamil), chloramphenicol, corticosteroids (such as prednisone), coumarins (such as warfarin), diuretics (such as furosemide and hydrochlorothiazide), estrogens, isoniazid, miconazole, monoamine oxidase inhibitors (MAOIs such as phenelzine), nicotinic acid, nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen and naproxen), oral contraceptives, phenothiazines (such as chlorpromazine), phenytoin, probenecid, salicylates (such as aspirin), sulfonamides (such as sulfamethoxazole and sulfisoxazole), sympathomimetics (such as albuterol), or thyroid drugs.

  • What are the possible side effects of Tolazamide?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: low blood sugar, bloating, heartburn, hives, itching, nausea, rash

  • Can I receive Tolazamide if I am pregnant or breastfeeding?

    The effects of tolazamide during pregnancy are unknown. Tell your doctor immediately if you are pregnant, or plan to become pregnant. Tolazamide is not recommended for treatment of diabetes in pregnant women. If prescribed, stop tolazamide at least 2 weeks before the expected delivery date. Your doctor may prescribe insulin during pregnancy to control your blood sugar levels.

    You should not breastfeed while on therapy with tolazamide. If you are planning to breastfeed, your doctor may stop the tolazamide and start you on insulin therapy.

  • What should I do if I miss a dose of Tolazamide?

    If you miss a dose of tolazamide, take it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to your regular schedule. Do not take two doses at the same time.

  • How should I store Tolazamide?

    Store at room temperature.

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I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

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