What is this medication and its most common uses?Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis. Tolmetin is available as capsules and tablets.
What should I know when beginning and continuing on this medication?How does this medication work?
Tolmetin blocks a substance in your body that is involved in causing inflammation and pain in parts of the body where there is arthritis.
What are the beneficial effects of this medication and when should I begin to have results?
What: Tolmetin has been shown to relieve arthritis symptoms, such as pain, swelling, and stiffness.
When: Tolmetin may start to work within a few days to a week.
How do I know it is working?
You may feel relief in your arthritis symptoms after you start taking tolmetin. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.
What are the possible side effects of this medication?The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Tolmetin may increase the chance of a life-threatening heart attack or stroke. The risk of heart attack or stroke may be increased with longer use and in people who have heart disease. Call your healthcare provider right away if you develop chest pain, shortness of breath, weakness, or slurring of your speech while taking tolmetin.
Tolmetin should never be used right before or after a heart surgery called a coronary artery bypass graft (CABG).
Tolmetin can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can be life-threatening and may happen without warning symptoms. The chance of a person getting an ulcer or bleeding increases with longer use, smoking, drinking alcohol, older age, having poor health, and if you are taking medicines called corticosteroids (such as prednisone) or blood thinners (such as warfarin). Call your healthcare provider right away if you develop stomach pain, indigestion, bloody or tarry stools, or you vomit blood while taking tolmetin.
More common side effects may include: nausea.
Less common side effects may include:
Liver problems with symptoms such as nausea, tiredness, weakness, itching, yellowing of your skin or the whites of your eyes, right upper stomach pain, and flu-like symptoms.
Serious allergic reactions with symptoms such as skin rash, blisters, fever, itching, trouble breathing, or swelling of your face or throat.
Tolmetin may cause high blood pressure, kidney or eye problems, anemia (low red blood cell counts), or unexplained weight gain or swelling.
Who should not take this medication?Do not take tolmetin if you are allergic to it or any of its ingredients.
Do not take tolmetin if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID (such as ibuprofen or naproxen).
Do not take tolmetin for pain right before or after a heart bypass surgery.
Do not take tolmetin during the late stages of your pregnancy.
What should I tell my healthcare provider before I take the first dose of this medication?Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with tolmetin. Also, talk to your healthcare provider about your complete medical history, especially if you have asthma; high blood pressure; heart failure; kidney or liver problems; a history of ulcers or bleeding in your stomach or intestines; or if you are pregnant, plan to become pregnant, or are breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Osteoarthritis and Rheumatoid Arthritis
Adults: The recommended starting dose is 400 milligrams three times a day.
Juvenile Rheumatoid Arthritis
Children ≥2 years: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight.
Your healthcare provider may adjust your or your child's dose as needed.
How should I take this medication?Take tolmetin exactly as prescribed by your healthcare provider. Do not change your dose without first talking to your healthcare provider.
What should I avoid while taking this medication?Do not take other NSAIDs in combination with tolmetin without first talking to your healthcare provider.
What are the possible food and drug interactions associated with this medication?If tolmetin is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining tolmetin with the following: aspirin, blood pressure/heart medications known as angiotensin-converting enzyme (ACE) inhibitors (such as enalapril and lisinopril), lithium, methotrexate, warfarin, or water pills (such as furosemide or hydrochlorothiazide).
May I receive this medication if I am pregnant or breastfeeding?Do not take tolmetin if you are in the late stage of your pregnancy. The effects of tolmetin during early pregnancy are unknown. Tolmetin can be found in your breast milk if you take it while breastfeeding. Do not breastfeed while you are taking tolmetin. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of this medication?If you miss a dose of tolmetin, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
How should I store this medication?Store at room temperature.