Generic Name: Metoprolol

  • What is this medication and its most common uses?

    Toprol-XL is a medicine known as a beta-blocker, which is used alone or in combination with other medicines to treat high blood pressure, chest pain, and heart failure.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Toprol-XL is an extended release medicine (a type of tablet that releases medicine into your body throughout the day). It works by decreasing your heart rate, and relaxing and widening your blood vessels, allowing your blood to flow through with less resistance. This helps to lower your blood pressure.

    What are the beneficial effects of this medication and when should I begin to have results?


    High Blood Pressure: By lowering your blood pressure, Toprol-XL may lower your risk of a stroke or a heart attack. Also, since Toprol-XL is an extended-release medicine, you only need to take it once a day, which may make it easier for you to remember to take your medicine.

    Chest Pain: Toprol-XL has been shown to reduce the number of chest pain attacks and improve exercise tolerance.

    Heart Failure: Toprol-XL has been shown to reduce the need for hospitalizations and the chance of death from heart failure.

    When: Toprol-XL may start lowering your blood pressure after 1 week of taking the medicine. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

    How do I know it is working?

    High Blood Pressure: Check your blood pressure regularly. Your healthcare provider will also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Do not stop taking Toprol-XL without first talking to your healthcare provider. Stopping Toprol-XL suddenly may cause severe chest pain or a heart attack.

    More common side effects may include: tiredness, dizziness, depression, shortness of breath, slow heartbeat, low blood pressure, diarrhea, itching, rash.

    Less common side effects may include:

    Breathing problems or worsened heart failure with symptoms such as weight gain, increased shortness of breath, or a slow heartbeat.

    Toprol-XL may hide symptoms of low blood sugar levels if you have diabetes.

  • Who should not take this medication?

    Do not take Toprol-XL if you are allergic to it or any of its ingredients.

    Do not take Toprol-XL if you have certain heart problems (such as heart failure, a slow heartbeat, or your heart skips a beat).

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Toprol-XL. Also, talk to your healthcare provider about your complete medical history, especially if you have lung problems (such as bronchitis or emphysema), problems with blood flow in your feet and legs, diabetes, pheochromocytoma (tumor of the adrenal gland), liver or thyroid problems, or if you are scheduled for surgery.

    Tell your healthcare provider if you have a history of severe allergic reactions to any allergens, because Toprol-XL may decrease the effectiveness of epinephrine, a medicine used to treat such reactions.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    High Blood Pressure

    Adults: The usual starting dose is 25 to 100 milligrams (mg) once a day. Your healthcare provider may increase your dose as needed until the desired effect is achieved.

    Children ≥6 years: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight.

    Chest Pain

    Adults: The usual starting dose is 100 mg once a day. Your healthcare provider may increase your dose as needed until the desired effect is achieved.

    Heart Failure

    Adults: The usual starting dose is 25 mg once a day. Your healthcare provider may increase your dose as appropriate.

    It is important that you do not stop taking this medication abruptly. If you need to change or stop taking this medication, it is important that you only do this with the guidance of your healthcare provider.

  • How should I take this medication?

    Take Toprol-XL exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Toprol-XL without first talking to your healthcare provider.

    Take Toprol-XL with or right after a meal.

    Your healthcare provider will tell you if you need to divide your Toprol-XL tablets based on the dose prescribed. Whether you are taking Toprol-XL whole or dividing the tablets, do not break, crush, or chew them.

  • What should I avoid while taking this medication?

    Do not drive a car, operate machinery, or engage in other tasks requiring alertness until you know how Toprol-XL affects you.

  • What are the possible food and drug interactions associated with this medication?

    If Toprol-XL is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Toprol-XL with the following: antidepressant medications known as monoamine oxidase inhibitors (MAOIs) (such as phenelzine or tranylcypromine), blood pressure/heart medications known as calcium channel blockers (such as diltiazem or verapamil), clonidine, digoxin, fluoxetine, paroxetine, propafenone, quinidine, or reserpine.

  • May I receive this medication if I am pregnant or breastfeeding?

    The effects of Toprol-XL during pregnancy are unknown. Toprol-XL can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Toprol-XL, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature.

Starting a Cholesterol Drug?

Our seven-week newsletter series, written by a pharmacist, will help you learn about your medication.
Sign Up

Meet the Pharmacists

I'm Beth Isaac, PharmD. Welcome to PDR Health!

Check out my latest post on cholesterol drugs.

Toprol-XL Related Drugs

Toprol-XL Related Conditions