Generic Name: Temsirolimus

  • What is Torisel?

    Torisel is used to treat advanced renal (kidney) cell carcinoma.
  • What is the most important information I should know about Torisel?

    You should be premedicated with IV diphenhydramine or another antihistamine around 30 minutes before each dose of Torisel. Allergic reactions such as flushing, shortness of breath, and chest pain may occur while using this medication. If you are allergic to Torisel or any of its metabolites (such as sirolimus), polysorbate 80 or any other component of this medication, use this with caution.

    Use Torisel with caution if you are allergic to antihistamines. Your serum glucose levels may increase, so make sure to report any excessive thirst or increase in the volume or frequency in urination. You also may be more likely to get infections because your immune system may be weaker.

  • Who should not take Torisel?

    If you are allergic to Torisel or any of its metabolites (such as sirolimus), polysorbate 80 or any other component of this medication.
  • What should I tell my doctor before I take the first dose of Torisel?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Torisel. Also, talk to your doctor about your complete medical history, especially if you have any allergies to this medication or any of its components. Tell your doctor if you are pregnant or plan to become pregnant because there is a potential for harm to the fetus.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended dose of Torisel is 25 milligrams (mg) infused over a 30- to 60-minute period once a week.

  • How should I take Torisel?

    This medication should be administered to you once weekly until disease progression or there are unacceptable adverse effects.
  • What should I avoid while taking Torisel?

    Avoid grapefruit juice as it may increase the effect of this medication.

    Avoid receiving any live vaccines (such as measles, mumps, rubella, oral polio, and varicella, etc.), or coming into close contact with anyone who have received a live vaccine. You should avoid getting pregnant throughout treatment and for 3 months after Torisel therapy has been stopped because of the potential harm to the fetus.

  • What are possible food and drug interactions associated with Torisel?

    If Torisel is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Torisel with atazanavir, carbamazepine, clarithromycin, dexamethasone, indinavir. itraconazole, ketoconazole, nefazodone, nelfinavir, phenobarbital, phenytoin, rifampin, rifabutin, rifampacin, ritonavir, saquinavir, sunitinib, telithromycin, and voriconazole.
  • What are the possible side effects of Torisel?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: rash, weakness, swelling of the mucous membranes, nausea, edema

  • Can I receive Torisel if I am pregnant or breastfeeding?

    Do not take this medication if you are pregnant or breastfeeding because of the potential harmful risk to the fetus.
  • What should I do if I miss a dose of Torisel?

    This drug is administered in a hospital or office setting. Be sure to keep all appointments and notify your doctor if you miss one.
  • How should I store Torisel?

    This drug is administered in a hospital or office setting.