Generic Name: Dexrazoxane

  • What is Totect?

    Totect is used to treat extravasation resulting from intravenous anthracycline.
  • What is the most important information I should know about Totect?

    Totect is a cytotoxic drug and when administered to patients on anthracycline, there could be increased toxicity causing decreased formation of red blood cells, white blood cells, and platelets.
  • Who should not take Totect?

    Do not use Totect if you are pregnant.
  • What should I tell my doctor before I take the first dose of Totect?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Totect. Also, talk to your doctor about your complete medical history, especially if you have any kidney problems.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual dose is 2000 milligrams (mg) on Day 1 and Day 2, followed by 1000 mg on Day 3:

  • How should I take Totect?

    Totect is administered as an intravenous infusion by your doctor.
  • What should I avoid while taking Totect?

    Avoid pregnancy. Notify your doctor immediately if you suspect you may be pregnant.
  • What are possible food and drug interactions associated with Totect?

    If Totect is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Totect with any other medications.
  • What are the possible side effects of Totect?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: nausea, vomiting, bone marrow suppression causing anemia, tendency for bleeding, infections, liver problems, infusion-site burning.

  • Can I receive Totect if I am pregnant or breastfeeding?

    Totect is to be avoided during pregnancy and breastfeeding.
  • What should I do if I miss a dose of Totect?

    Totect is administered by your doctor in an office or hospital.
  • How should I store Totect?

    Since Totect is given in your doctor's office, this is not an issue.