Generic Name: Clorazepate

  • What is Tranxene?

    Tranxene is used to manage anxiety disorders and for the short-term relief of anxiety symptoms. The drug is also used to relieve the symptoms of acute alcohol withdrawal and to help in treating certain convulsive disorders, such as epilepsy.

  • What is the most important information I should know about Tranxene?

    Tranxene may be habit-forming if taken regularly over a long period. You may experience withdrawal symptoms if you stop using this drug abruptly. Consult your doctor before discontinuing Tranxene or making any change in your dose.

    You should not take this medication for use in depressive neuroses or in psychotic reactions.

    You should avoid driving a car or operating hazardous machinery until you know how tranxene affects you. It may cause drowsiness and dizziness. You should also avoid alcohol and other central nervous system (CNS) depressants because they can intensify these side effects.

    Tranxene may increase the risk of suicidal ideas and behavior; therefore, careful monitoring is advised in patients for new or worsening depression, suicidal ideas and behavior, and any unusual changes in mood or behavior.

  • Who should not take Tranxene?

    Do not use Tranxene if you have a known hypersensitivity to the drug or if you have an eye condition known as acute narrow-angle glaucoma.

  • What should I tell my doctor before I take the first dose of Tranxene?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Tranxene. Also, talk to your doctor about your complete medical history, especially if you are being treated for depression or anxiety or if you have a history of drug abuse or dependence.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Tranxene T-Tab is administered orally in divided doses. The usual daily dose is 30 milligrams (mg). The dose should be adjusted gradually within the range of 15-60 mg daily, depending on your response. In elderly or debilitated patients, treatment may start at a daily dose of 7.5-15 mg. It can be given as a single dose at bedtime starting at 15 mg.

    Alcohol Withdrawal Symptoms
    Adults: Your doctor will provide a schedule of reducing daily doses until your condition is stable.

    Add-on Therapy with Antiepileptic Drugs
    Adults and children >12 years: The starting dose is 7.5 mg three times a day. Your doctor may increase the dosage by 7.5 mg per week to a maximum of 90 mg a day.

    Children 9-12 years: The starting dose is 7.5 mg two times a day. Your doctor may increase the dosage by 7.5 mg per week to a maximum of 60 mg a day.

  • How should I take Tranxene?

    Take Tranxene exactly as prescribed. Do not increase the amount you take or the number of doses per day without your doctor's approval. Do not stop taking Tranxene without talking to your doctor.

  • What should I avoid while taking Tranxene?

    Avoid driving a car or operating machinery until you know how Tranxene affects you. Also avoid alcohol and other CNS depressants while taking this drug.

  • What are possible food and drug interactions associated with Tranxene?

    If Tranxene is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Always check with your doctor before combining Tranxene with the following: antidepressants including monoamine oxidase inhibitors or tricyclics, antipsychotics, barbiturates, narcotic pain relievers, and alcohol or other CNS depressants.

  • What are the possible side effects of Tranxene?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: drowsiness, dizziness, stomach complaints, nervousness, blurred vision, dry mouth, headache, mental confusion

  • Can I receive Tranxene if I am pregnant or breastfeeding?

    Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding before taking this drug. Tranxene should not be given to nursing mothers.

  • What should I do if I miss a dose of Tranxene?

    Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take two doses at the same time.

  • How should I store Tranxene?

    Store at room temperature in a tightly closed, light-resistant container. Protect from moisture and excessive heat.

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I'm Beth Isaac, PharmD. Welcome to PDR Health!

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