Generic Name: Pentoxifylline

  • What is Trental?

    Trental is used to relieve the painful leg cramps caused by intermittent claudication, a condition that results when hardening of the arteries reduces the leg muscles' blood supply. Trental reduces the viscosity, or stickiness, of your blood, allowing it to flow more freely.

  • What is the most important information I should know about Trental?

    Trental can ease the pain in your legs and make walking easier but should not replace other treatments, such as physical therapy or surgery.

  • Who should not take Trental?

    Do not take Trental if you have recently had a stroke or bleeding in the retina of your eye.

    If you are sensitive to or have ever had an allergic reaction to Trental, caffeine, theophylline, or theobromine, do not take Trental. Make sure that your doctor is aware of any drug reactions that you have experienced.

    The safety and effectiveness of Trental have not been established in children.

  • What should I tell my doctor before I take the first dose of Trental?

    Mention all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Trental. Also, talk to your doctor about your complete medical history, especially if you have ulcers, undergone any type of surgery (including dental), or if you have an irregular heartbeat caused by heart disease or a brain disorder. Make sure to let your doctor know if you have a bleeding disorder, liver disease, crushing chest pain, or low blood pressure.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual dosage of Trental in controlled-release tablets is one 400-milligram (mg) tablet three times a day with meals. While the effect of Trental may be seen within 2 to 4 weeks, it is recommended that treatment be continued for at least 8 weeks.

  • How should I take Trental?

    Trental comes in controlled-release tablets. Do not break, crush, or chew the tablets; swallow them whole. Take Trental exactly as prescribed.

  • What should I avoid while taking Trental?

    Avoid using tobacco while you are taking Trental. Tobacco may worsen your condition or decrease the beneficial effects of Trental by narrowing your blood vessels.

  • What are possible food and drug interactions associated with Trental?

    If Trental is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Trental with the following: cimetidine, diltiazem, dipyridamole, enalapril, theophylline, or warfarin.

  • What are the possible side effects of Trental?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: agitation/nervousness, blurred vision, chest pain, confusion, depression, diarrhea, difficult or labored breathing, dizziness, dry mouth/thirst, flushing, general body discomfort, headache, indigestion, insomnia, irregular heart beat, nausea, tremor, vomiting.

  • Can I receive Trental if I am pregnant or breastfeeding?

    The effects of Trental during pregnancy are unknown, and should be used during pregnancy only if the potential benefits justify the potential risk to the fetus. Tell your doctor immediately if you are pregnant, or plan to become pregnant.

    Trental appears in breast milk and could affect a nursing infant. If Trental is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with Trental is finished.

  • What should I do if I miss a dose of Trental?

    If you miss a dose of Trental, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once. If you are unsure, ask your doctor or pharmacist for advice.

  • How should I store Trental?

    Store Trental at room temperature, tightly closed and away from light.

Meet the Pharmacists

I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

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