What is Treximet?Treximet is used to treat migraine attacks in adults. It does not, however, prevent or reduce the number of migraines you have, nor is it used for other types of headaches.
What is the most important information I should know about Treximet?Treximet contains two medications, sumatriptan and naproxen (a nonsteroidal anti-inflammatory drug, or NSAID). NSAIDs may increase the chance of heart attack or stroke. The risk is greater if you have heart disease or use Treximet for a long time. Get emergency help immediately if you experience any of the following: shortness of breath, chest pain, weakness in one part or side of the body, slurred speech, or sudden heaviness in your chest, throat, neck, or jaw.
NSAIDs should never be used before or after heart bypass (CABG) surgery.
NSAIDs can also increase the risk of serious stomach and intestinal problems, including bleeding, ulceration, and perforation of the stomach, which can be fatal. These events can occur at any time during use and without warning. Elderly patients are at a greater risk.
Treximet can cause a reaction known as serotonin syndrome (a potentially life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by the nerve cells). This reaction is more likely to occur when Treximet is combined with certain antidepressants. Tell your doctor immediately if you develop any of the following: agitation, fast heartbeat, high or low blood pressure, fever or sweating, tight muscles, hallucinations, difficulty walking, nausea, vomiting, or diarrhea.
As with other medicines containing NSAIDs, Treximet can cause serious--and possibly life-threatening--allergic reactions. Contact your doctor immediately if you experience any of the following: nausea, unusual tiredness or weakness, itching, jaundice (yellowing of the skin or whites of the eyes), stomach pain, flu symptoms, vomiting blood or the appearance of blood in the stools (such as black stools), unusual weight gain, skin rash or blisters accompanied by a fever, or swelling of the arms, legs, hands, and feet.
Treximet may cause liver problems. Contact your doctor if you experience any of the following: nausea, unusual tiredness or weakness, rash, jaundice, pain in the upper right part of the stomach, or flu-like symptoms.
Who should not take Treximet?Do not take Treximet if you are scheduled to have, or have recently undergone, heart bypass (CABG) surgery.
Do not use Treximet if you have uncontrolled high blood pressure, liver problems, a history of stroke or heart disease, symptoms of heart disease (such as chest pain), asthma, or have had allergic reactions to aspirin, any other NSAID, or sumatriptan.
Do not take Treximet with monoamine oxidase (MAO) inhibitors.
What should I tell my doctor before I take the first dose of Treximet?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Treximet. Also talk to your doctor about your complete medical history, especially if you have shortness of breath, chest pain, heart problems (including irregular heartbeat), kidney or liver problems, seizures, allergies to aspirin or other NSAIDs, or if you are pregnant, plan to become pregnant, or are breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: The recommended dose is 1 tablet. Do not take more than 2 tablets in 24 hours, and separate the doses by at least 2 hours.
How should I take Treximet?Take Treximet exactly as prescribed. It can be taken with or without food. Do not chew, crush, or split the tablets.
What should I avoid while taking Treximet?Avoid smoking and drinking alcohol to reduce your risk of getting ulcers or stomach bleeding.
What are possible food and drug interactions associated with Treximet?If Treximet is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Treximet with the following: blood pressure drugs known as ACE inhibitors, aspirin and other NSAIDs, blood thinners, steroid medications, SSRIs (such as citalopram, escitalopram, paroxetine, fluoxetine, olanzapine/fluoxetine, sertraline, and fluvoxamine), SNRIs (such as duloxetine and venlafaxine), cyclosporine, diuretics, lithium, and methotrexate.
Do not take Treximet within 2 weeks of starting or stopping certain antidepressants and Parkinson's drugs known as MAO inhibitors.
Do not take Treximet within 24 hours of certain migraine drugs, including triptans and ergotamines such as the following: almotriptan, dihydroergotamine, ergotamine, frovatriptan, methysergide, naratriptan, rizatriptan, sumatriptan, and zolmitriptan.
What are the possible side effects of Treximet?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: pain in the neck, chest, throat, or stomach; constipation; diarrhea; gas; heartburn; nausea and vomiting; dizziness; drowsiness; tingling and numbness
Can I receive Treximet if I am pregnant or breastfeeding?Treximet should be avoided during pregnancy and breastfeeding.
What should I do if I miss a dose of Treximet?If you miss a dose, take it as soon as you remember. If it is within 12 hours of your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
How should I store Treximet?Store at room temperature.
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