Generic Name: Olmesartan

  • What is this medication and its most common uses?

    Tribenzor is a medicine used to treat high blood pressure. Tribenzor contains three medicines that work in different ways to reduce your blood pressure: amlodipine, olmesartan, and hydrochlorothiazide.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Amlodipine and olmesartan work by blocking substances in your body that cause blood vessels to narrow. By blocking these substances, amlodipine and olmesartan relax and widen your blood vessels, allowing your blood to flow through with less resistance. Hydrochlorothiazide works by eliminating extra fluid and sodium (salt) from your body. This helps to lower your blood pressure.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: By lowering your blood pressure, Tribenzor may lower your risk of a stroke or a heart attack. Also, it is taken just once a day, which may make it easier for you to remember.

    When: Tribenzor may start lowering your blood pressure within 2 weeks. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

    How do I know it is working?

    Check your blood pressure regularly. Your healthcare provider may also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Tribenzor can harm your unborn baby. Talk to your healthcare provider about other ways to lower your blood pressure if you plan to become pregnant. Tell your healthcare provider right away if you become pregnant while taking Tribenzor.

    More common side effects may include: dizziness; swelling of your legs, ankles, or hands; headache; tiredness; runny or stuffy nose; muscle twitching or spasms; nausea; upper respiratory infection; diarrhea; urinary tract infection; joint swelling.

    Less common side effects may include:

    Low blood pressure with symptoms such as fainting or dizziness.

    Possible increased chest pain or risk of a heart attack.

    Kidney problems with symptoms such as swelling in your feet, ankles, or hands; or unexplained weight gain.

    Changes in electrolytes (chemicals that are important for the cells in your body to function, such as sodium and potassium) with symptoms such as dry mouth, thirst, weakness, tiredness, drowsiness, restlessness, muscle pains or cramps, muscle tiredness, dizziness or fainting, low or no urine output, fast heartbeat, or nausea and vomiting.

    Serious allergic reactions with symptoms such as extreme swelling of your face, lips, tongue, or throat.

    Temporary nearsightedness (trouble seeing objects farther away) or glaucoma (high pressure in the eye) with symptoms such as changes in your vision or eye pain that may occur within hours to weeks of starting Tribenzor.

    Severe, chronic (long-term) diarrhea with considerable weight loss.

  • Who should not take this medication?

    Do not take Tribenzor if you are allergic to it, any of its ingredients, or other sulfonamide-derived medications (such as sulfamethoxazole).

    Do not take Tribenzor if you are unable to produce urine.

    Do not take Tribenzor if you have diabetes and are taking another blood pressure medicine called aliskiren.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Tribenzor. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes; asthma; heart, liver, or kidney problems; lupus (a disease that affects the immune system); gout; are vomiting or have a lot of diarrhea; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: Your healthcare provider will prescribe the appropriate dose for you based on your previous blood pressure medication, and may increase your dose as needed, until the desired effect is achieved.

  • How should I take this medication?

    Take Tribenzor exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Tribenzor without first talking to your healthcare provider.

    Take Tribenzor once a day, with or without food.

    If you take a cholesterol-lowering medicine called colesevelam, take Tribenzor at least 4 hours before you take this medicine.

  • What should I avoid while taking this medication?

    Do not become pregnant while taking this medication.

    Do not drink alcohol while taking this medication.

  • What are the possible food and drug interactions associated with this medication?

    If Tribenzor is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Tribenzor with the following: alcohol, barbiturates (such as phenobarbital), blood pressure/heart medications known as angiotensin-converting enzyme (ACE) inhibitors (such as enalapril or lisinopril), cholestyramine, colesevelam, colestipol, diabetes medicines (such as insulin or glyburide), lithium, narcotic painkillers (such as hydrocodone or oxycodone), nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen or naproxen), norepinephrine, potassium supplements, salt substitutes containing potassium, simvastatin, or steroids (such as prednisone).

  • May I receive this medication if I am pregnant or breastfeeding?

    Do not take Tribenzor if you are pregnant or breastfeeding. Tribenzor may harm your unborn baby. Tribenzor can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Tribenzor, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature.