What is Trizivir?Trizivir is a medicine used to treat HIV (human immunodeficiency virus) infection (AIDS). Trizivir contains three medications: abacavir sulfate, lamivudine, and zidovudine. All three of these medications are types of HIV medications called nucleoside reverse transcriptase inhibitors (NRTIs).
What is the most important information I should know about Trizivir?Trizivir can cause a serious allergic reaction that can lead to death. Your risk of this allergic reaction is much higher if you have a certain gene variation. Your doctor can determine with a blood test if you have this gene variation. If you experience a symptom from two or more of the groups listed on the warning card that comes with Trizivir, tell your doctor immediately. Carry this warning card with you at all times.
If you stop Trizivir because of an allergic reaction, do not take Trizivir or any other abacavir-containing medicine (such as Ziagen or Epzicom) again. If you stop Trizivir, for any other reason, even for a few days, and you are not allergic to it, talk with your doctor before taking it again.
Trizivir does not cure HIV, nor does it reduce the risk of passing HIV to others through sexual contact, sharing needles, or being exposed to your blood.
Trizivir can cause serious blood cell problems such as low neutrophil counts (a type of blood cell that helps to fight infections) and anemia (reduced number of red blood cells). Your doctor will check your blood cell counts regularly while you are taking Trizivir.
Trizivir can cause a rare but serious condition called lactic acidosis (a build-up of an acid in the blood) with liver enlargement. You have a higher chance of getting lactic acidosis or liver problems if you are a woman, are very overweight, or if you have been taking Trizivir or similar products for a long time.
Trizivir can cause myopathy (muscle weakness). Tell your doctor immediately if you experience muscle pain or weakness.
If you have hepatitis B virus (HBV) and stop taking Trizivir, your HBV can worsen.
Who should not take Trizivir?Do not take Trizivir if you are allergic to it or any of its ingredients. Also, do not take Trizivir if you have liver disease or if you are an adolescent who weighs less than 90 pounds.
What should I tell my doctor before I take the first dose of Trizivir?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Trizivir. Also, talk to your doctor about your complete medical history, especially if you have liver or kidney disease, low blood cell counts, heart problems, high blood pressure, high cholesterol, diabetes, or if you smoke.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults and adolescents ≥90 pounds: The recommended dose is 1 tablet twice a day.
How should I take Trizivir?Take Trizivir exactly as prescribed by your doctor. Take it with or without food.
When your Trizivir supply runs low, renew your prescription promptly. If you stop the medicine for even a short time, the amount of HIV in your body can increase or it can become resistant to the effects of Trizivir.
What should I avoid while taking Trizivir?Do not become pregnant or breastfeed while you are taking Trizivir. If you do become pregnant, tell your doctor immediately.
Do not reuse or share needles or other injection equipment. Also, do not share personal items that can have blood or bodily fluids on them (such as toothbrushes or razor blades).
Do not have unprotected sex.
Do not take other medications that contain components of Trizivir (such as Combivir, Epivir, Epzicom, Retrovir, or Ziagen).
What are possible food and drug interactions associated with Trizivir?If Trizivir is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Trizivir may interact with numerous medications. Therefore, it is very important that you tell your doctor about any other medications you are taking.
What are the possible side effects of Trizivir?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: abdominal cramps, abdominal pain, allergic reactions, blisters in the mouth or eyes, blood and lymph disorders, breast enlargement in males, chills, cough, depression, diarrhea, dizziness, enlarged spleen, fatigue, fever, hair loss, headache, heart problems, high blood sugar, hives, ill feeling, indigestion, inflamed blood vessels, joint pain, liver problems, loss of appetite, mouth inflammation, muscle pain or weakness, nasal (nose) symptoms, nausea, pain or tingling in the hands or feet, pancreatitis (inflammation of the pancreas), redistribution of body fat, seizures, severe peeling skin, skin rash, trouble sleeping and other sleep problems, vomiting, weakness, wheezing
Can I receive Trizivir if I am pregnant or breastfeeding?The effects of Trizivir during pregnancy and breastfeeding are unknown. It is recommended that you do not breastfeed your baby if you are infected with HIV. This is because your baby could become infected with HIV through your breast milk. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Trizivir?If you miss a dose of Trizivir, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
How should I store Trizivir?Store at room temperature.