Tykerb

Generic Name: Lapatinib

  • What is Tykerb?

    Tykerb is used with the medicine capecitabine for the treatment of patients with advanced or metastatic breast cancer that is HER2 positive, and who have already had certain other breast cancer treatments.
  • What is the most important information I should know about Tykerb?

    Do not use Tykerb for any other condition for which it was not prescribed. Do not give Tykerb to other people, even if they have the same condition that you have. It may harm them.

    Do not eat or drink grapefruit products while taking Tykerb.

    Tykerb has been shown to be toxic to the liver. You will need to get frequent liver function tests before and during the course of the treatment

  • Who should not take Tykerb?

    You should not use Tykerb unless you have already been treated with other drugs for breast cancer.
  • What should I tell my doctor before I take the first dose of Tykerb?

    Tell your doctor about all prescription, over-the-counter, and herbal medication you are taking before beginning treatment with Tykerb. Also, talk to your doctor about your complete medical history, especially if you have heart problems or liver problems. You may need a lower dose of Tykerb.

    Inform your doctor if you are pregnant, planning to become pregnant, or if you are breastfeeding

    If you take certain drugs with Tykerb, a dosage adjustment may be required. Especially tell your doctor if you take antibiotics and antifungals (drugs used to treat infections), HIV (AIDS) treatments, anticonvulsant drugs (drugs used to treat seizures), calcium channel blockers (drugs used to treat certain heart disorders or high blood pressure), antidepressants, drugs used for stomach ulcers, St. John's Wort, or other herbal supplements.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual dose is 1,250 milligrams (5 tablets) once daily on days 1 to 21 in combination with capecitabine, in a repeating cycle.

    If you have impaired liver function, your dose may be decreased to 750 mg per day. Your doctor may increase or decrease the dose, depending on the other medications you may be taking.

  • How should I take Tykerb?

    Take Tykerb exactly as your doctor has told you. Tykerb and capecitabine are taken in 21 day cycles.

    Tykerb should be taken at least one hour before or at least one hour after food.

    The dose of Tykerb should not be divided; it should only be taken once a day. (Note that capecitabine is taken twice daily.)

  • What should I avoid while taking Tykerb?

    Many medications interact with Tykerb. Avoid taking any medications without your doctor's approval.
  • What are possible food and drug interactions associated with Tykerb?

    If Tykerb is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Tykerb with the following: atazanavir, carbamazepine, clarithromycin, dexamethasone, grapefruit juice, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, phenobarbital, phenytoin, rifabutin, rifampin, rifapentin, ritonavir, saquinavir, St. John's wort, telithromycin, and voriconazole.
  • What are the possible side effects of Tykerb?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: back pain, diarrhea, dry skin, pain in extremity, fatigue, heart problems such as decreased pumping of blood from the heart and abnormal heartbeat, indigestion, insomnia, loss of appetite, lung problems, mouth sores, nausea, palpitations, rash, red and painful hands and feet, shortness of breath, severe diarrhea, tiredness, vomiting

    These are not all the side effects with Tykerb. Ask your doctor or pharmacist for more information. Tell your doctor about any side effect that becomes serious or that does not go away.

    Some side effects your doctor will monitor include liver problems, severe diarrhea, QT prolongation, a decrease in left ventricular dysfunction.

  • Can I receive Tykerb if I am pregnant or breastfeeding?

    Tykerb may cause fetal harm when administered to a pregnant woman. Women should not become pregnant when taking Tykerb. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.

    It is not known whether lapatinib is excreted in human milk. Because many drugs are excreted in milk and because of the potential for serious adverse reactions in nursing infants from Tykerb, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

  • What should I do if I miss a dose of Tykerb?

    If you forget to take your dose of Tykerb, take it as soon as you remember that day. If you miss a day, do not double your dose the next day. Just skip the missed dose.
  • How should I store Tykerb?

    Store Tykerb tablets at room temperature in a tightly closed container.