Generic Name: Telbivudine

  • What is Tyzeka?

    Tyzeka is an antiviral medicine used to treat chronic (long-term) hepatitis B virus (HBV) infection. Tyzeka can help lower the amount of HBV in your body. Tyzeka is available in tablets and an oral solution.

  • What is the most important information I should know about Tyzeka?

    Tyzeka does not cure your chronic HBV infection, nor does it reduce the risk of passing HBV to others through sexual contact or blood contamination.

    Worsening of your HBV infection can occur if you stop taking Tyzeka. Your doctor will monitor your health and order regular blood tests to check your liver function and HBV virus levels if you stop taking Tyzeka. Tell your doctor about any new or unusual symptoms after you stop taking Tyzeka.

    Tyzeka can cause a rare but serious condition called lactic acidosis (a build-up of an acid in the blood). Tell your doctor immediately if you feel very weak or tired; have unusual muscle pain, trouble breathing, or stomach pain with nausea and vomiting; feel cold, especially in your arms and legs; feel dizzy or lightheaded; or have a fast or irregular heartbeat.

    Tyzeka can cause serious liver problems with liver enlargement and fat in the liver. Tell your doctor immediately if you experience yellowing of your skin or whites of your eyes, dark urine, light-colored stools, loss of appetite, nausea, or lower abdominal pain.

    Tyzeka can cause muscle problems, including unexplained muscle pain, muscle weakness, muscle tenderness, or muscle breakdown. Muscle breakdown can lead to kidney damage. Tell your doctor immediately if you have unexplained muscle aches, pain, tenderness, or weakness.

    Tyzeka can cause nerve problems. Tell your doctor immediately if you experience numbness, tingling, burning sensations in your arms or legs, or problems walking. Your risk can increase if you take Tyzeka with any type of injectable interferon product. Be sure to tell your doctor if you are also being treated with any type of injectable medicines (such as interferon) for chronic hepatitis B or C.

    Tyzeka oral solution contains sodium. Ask your doctor for advice if you are on a low-sodium diet.

  • Who should not take Tyzeka?

    Do not take Tyzeka if you are allergic to it or any of its ingredients, or if you are also taking Pegasys (pegylated interferon alfa-2a).

  • What should I tell my doctor before I take the first dose of Tyzeka?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Tyzeka. Also, talk to your doctor about your complete medical history, especially if you have kidney problems, have any allergies, are on a low-sodium diet, or are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults and adolescents ≥16 years: The recommended dose is 600 milligrams (mg) (1 tablet or 30 milliliters [ml] of the oral solution) once a day.

    If you have kidney impairment, your doctor will adjust your dose appropriately.

  • How should I take Tyzeka?

    Take Tyzeka exactly as prescribed by your doctor, and at the same time each day. Do not change your dose or stop taking Tyzeka without first talking to your doctor.

    You can take Tyzeka with or without food. If you have difficulty swallowing the tablets, your doctor may prescribe Tyzeka oral solution.

  • What should I avoid while taking Tyzeka?

    Do not breastfeed while you are taking Tyzeka.

    Do not share needles or other injection equipment. Also, do not share personal items that can have blood or body fluids on them (such as toothbrushes or razor blades).

    Do not have unprotected sex.

  • What are possible food and drug interactions associated with Tyzeka?

    If Tyzeka is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is important to check with your doctor before combining Tyzeka with any other medication.

  • What are the possible side effects of Tyzeka?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: abdominal pain, abdominal swelling, back pain, cough, diarrhea, dizziness, fever, headache, joint pain, muscle aches, nausea, skin rash, sore throat, tiredness, trouble sleeping, upset stomach

  • Can I receive Tyzeka if I am pregnant or breastfeeding?

    The effects of Tyzeka during pregnancy and breastfeeding are unknown. Do not breastfeed while you are taking Tyzeka. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Tyzeka?

    If you miss a dose of Tyzeka, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Tyzeka?

    Store the tablets and the solution in the original bottle at room temperature. Do not freeze the solution; use it within 2 months after opening the bottle.