Vfend

Generic Name: Voriconazole

  • What is Vfend?

    Vfend is used in adults and children who are 12 years and older to treat certain fungal infections in your blood and body. These infections are called aspergillosis, esophageal candidiasis, scedosporiosis, fusariosis, and candidemia.
  • What is the most important information I should know about Vfend?

    Vfend is a potent antifungal medication and its use must be closely monitored by a healthcare professional. Prolonged use of Vfend may cause you to experience serious changes in heart rate or rhythm, changes in your vision, liver problems, and kidney problems.

    It is important to notify your physician of all prescription, nonprescription, and herbal medications you are taking. It is contraindicated to take Vfend with any of the following drugs: terfenadine, astemizole, cisapride, pimozide, quinidine, sirolimus, rifampin, carbamazepine, long-acting barbiturates (such as phenobarbital), ritonavir, efavirenz, rifabutin, ergot alkaloids (such as ergotamine and dihydroergotamine), methysergide, bromocriptine, or St. John's wort.

    Vfend, if used during pregnancy may cause fetal harm.

    Vfend tablets should not be given to you if you have galactose intolerance.

  • Who should not take Vfend?

    You should not take Vfend if you are allergic to any of its components. In addition, you should not take Vfend if you are taking certain medications, including terfenadine, astemizole, cisapride, pimozide, quinidine, sirolimus, rifampin, carbamazepine, long-acting barbiturates (such as phenobarbital), ritonavir, efavirenz, rifabutin, ergot alkaloids (such as ergotamine and dihydroergotamine), methysergide, bromocriptine, or St. John's wort.
  • What should I tell my doctor before I take the first dose of Vfend?

    Tell your doctor about all your health conditions and all the medicines you are currently taking, including prescription and over-the-counter medicines, vitamins, supplements, and herbals. Notify your doctor if you have or ever had an abnormal heart rate or rhythm, have liver or kidney problems, have trouble digesting dairy products, lactose, or regular table sugar, have had an allergic reaction to any other medication, are pregnant or planning to become pregnant, or are breast feeding.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    The following recommended doses are for patients over 18 years old. If Vfend is used in patients 12 to 18 years old, the dose will be determined by your doctor.

    Invasive Aspergillosis

    Adults (patients over 18 years old): The recommended initial dose is 6 milligrams (mg) per 2.2 pounds of body weight given intravenously (IV) every 12 hours for the first 24 hours of therapy. After the first 24 hours, the recommended dose will either be 4 milligrams (mg) per 2.2 pounds of body weight given intravenously (IV) every 12 hours, or 200 milligrams (mg) given by mouth every 12 hours if you weigh 88 pounds or more, or 100 mg every 12 hours given by mouth if you weigh less than 88 pounds. The duration of therapy will vary based on your disease state, if you are immunosuppressed (have a weakened immune system), and your response to therapy.

    Candidemia in Nonneutropenic Patients and Other Deep Tissue Candida Infections

    Adults (patients over 18 years old): The recommended initial dose is 6 milligrams (mg) per 2.2 pounds of body weight given intravenously (IV) every 12 hours for the first 24 hours. After the first 24 hours of treatment, the recommended dose will is 3 to 4 milligrams (mg) given intravenously (IV) every 12 hours, or 200 milligrams (mg) given by mouth every 12 hours if you weigh 88 pounds or more, or 100 milligrams (mg) every 12 hours given by mouth if you weigh less than 88 pounds. Therapy should continue for at least 14 days after all of your symptoms have resolved or for 14 days after your last positive culture, whichever one is longer.

    Esophageal Candidiasis

    Adults (patients over 18 years old): The recommended dose is 200 milligrams (mg) given by mouth every 12 hours if you weigh 88 pounds or more or 100 milligrams (mg) given by mouth every 12 hours. Treatment should continue for at least 14 days and for at least 7 days after all of your symptoms have resolved.

    Scedosporiosis and Fusariosis

    Adults (patients over 18 years old): The recommended initial dose is 6 milligrams (mg) per 2.2 pounds of body weight given intravenously (IV) every 12 hours for the first 24 hours. After the first 24 hours of treatment, the recommended dose is 4 milligrams (mg) per 2.2 pounds of body weight given every 12 hours, or 200 milligrams (mg) given by mouth every 12 hours if you weigh 88 pounds or more, or 100 milligrams (mg) given by mouth every 12 hours if you weigh less than 88 pounds. The duration of therapy will vary based on your disease state, if you are immunosuppressed (have a weakened immune system), and your response to therapy.

  • How should I take Vfend?

    Vfend comes in an intravenous (IV), tablet, and oral liquid forms.

    If you receive the intravenous (IV) form, then your doctor or nurse will give it to you through a needle in your vein. It will take between one and two hours to receive a dose of Vfend.

    If you are taking Vfend in the tablet or oral liquid form, then you should take your dose at least 1 hour before or at least 1 hour after meals unless otherwise directed by your physician.

    Vfend is usually taken every 12 hours.

  • What should I avoid while taking Vfend?

    Avoid night driving, because this medication may cause vision problems like blurry vision.

    Avoid all driving or using dangerous machinery, if you have any change in your eye sight.

    Avoid bright sunlight because skin may burn more easily and light may bother the eyes. Therefore, wear sunscreen, protective clothing, a hat, and sunglasses.

    The suspension contains sucrose and may not be for some patients who have difficulty absorbing or tolerating certain sugars.

  • What are possible food and drug interactions associated with Vfend?

    If Vfend is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Vfend with the following: alfetanil; astemizole; barbiturates such as phenobarbital; carbamazepine; cisapride; ergotamine, dihydroergotamine, methysergide, and bromocriptine; pimozide; quinidine; rifabutin; rifampin; ritonavir and efavirenz; sirolimus; St. John's wort; and terfenadine.
  • What are the possible side effects of Vfend?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: body aches, chest pain, cough, diarrhea, fever, headache, increased blood pressure, injection site reactions, shortness of breath, swelling in the arms and legs, vomiting

  • Can I receive Vfend if I am pregnant or breastfeeding?

    Vfend can cause fetal harm. If you are a woman of childbearing age, use an effective form of contraception to prevent pregnancy while on therapy with Vfend. Notify your physician if you are pregnant or planning to become pregnant prior to beginning therapy with Vfend.

    You should avoid breastfeeding while on therapy with Vfend unless your physician has told you otherwise.

  • What should I do if I miss a dose of Vfend?

    If you miss a dose of Vfend tablets or oral solution, take it as soon as you remember. If it is more than 6 hours since your missed your dose, wait. Do not take the missed dose. Take Vfend at the next regular dosing time. Do not take a double dose.

    Notify your physician if you have missed receiving a dose of Vfend intravenous (IV) form.

  • How should I store Vfend?

    Store Vfend tablets and liquid at room temperature. Do not refrigerate or freeze. The liquid should be discarded after 14 days. Keep all containers tightly closed. Intravenous Vfend should be given by your nurse or doctor.