Generic Name: Didanosine

  • What is Videx?

    Videx is one of the drugs used to fight human immunodeficiency virus (HIV)—the cause of AIDS. Over a period of years, HIV slowly destroys the immune system, leaving the body defenseless against infection. Videx disrupts reproduction of HIV, thereby staving off the immune system's collapse.

    Signs and symptoms of advanced HIV infection include diarrhea, fever, headache, infections, nervous system problems, rash, sore throat, and significant weight loss.

  • What is the most important information I should know about Videx?

    Although Videx can slow the progress of HIV, it is not a cure. You may continue to develop complications, including frequent infections. Even if you feel better, regular physical exams and blood counts are highly advisable. And notify your doctor immediately if you experience any changes in your general health.

    Pancreatitis has occurred during therapy with Videx used alone or in combination regimens.

  • Who should not take Videx?

    You should not take Videx if you have an allergy to Videx or any of its ingredients.
  • What should I tell my doctor before I take the first dose of Videx?

    Mention all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Videx. Also, talk to your doctor about your complete medical history, especially if you have a history of pancreatitis (inflammation of the pancreas), kidney disease, hepatitis or other liver problems, alcohol abuse, or if you are pregnant or are planning to become pregnant.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: If you weigh more than 132 pounds, the usual dose is 200 milligrams (mg) taken twice daily. If you weigh less than 132 pounds, the usual dose is

    125 mg taken twice daily. A once daily dosing regimen is also available.

    Children: The recommended dose of Videx in pediatric patients between 2 weeks and 8 months of age is 100 mg/m2 twice daily, and the recommended Videx dose for pediatric patients older than 8 months is 120 mg/m2 twice daily.

    Dosing recommendations for Videx in patients less than 2 weeks of age cannot be made because the pharmacokinetics of didanosine in these children is too variable to determine an appropriate dose. There are no data on once-daily dosing of Videx in pediatric patients.

  • How should I take Videx?

    Videx should be taken on an empty stomach, at least 30 minutes before or 2 hours after eating. You should swallow the capsule whole; do not open or crush the capsules.
  • What should I avoid while taking Videx?

    You should not drink alcohol or become pregnant while taking Videx. You should also not take any other medications, vitamins, or supplements without first checking with your doctor.
  • What are possible food and drug interactions associated with Videx?

    If Videx is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Videx with the following: allopurinol, ciprofloxacin, delavirdine, ganiciclovir, methadone, nelfinavir, ranitidine, rifabutin, ritonavir, stavudine, sulfamethoxazole, tenofovir, trimethoprim, and zidovudine.
  • What are the possible side effects of Videx?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: changes in body fat, diarrhea, headache, nausea, pain/numbness/tingling in hands or feet, rash

    Serious side effects include: lactic acidosis, liver failure, pancreatitis

  • Can I receive Videx if I am pregnant or breastfeeding?

    Videx during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    The Centers for Disease Control and Prevention recommends that HIV-infected mothers not breastfeed their infants to avoid risking postnatal transmission of HIV.

  • What should I do if I miss a dose of Videx?

    If you forget to take Videx, take the missed dose right away. If it is almost time for your next dose, do not take the missed dose. Instead, follow your regular dosing schedule by taking the next dose at its regular time.
  • How should I store Videx?

    Store at room temperature and away from children.