What is Vimovo?Vimovo contains two medicines: naproxen, a nonsteroidal anti-inflammatory drug (NSAID) and esomeprazole magnesium, a proton pump inhibitor (PPI). Vimovo is used to relieve signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis (arthritis of the spine). It is also used to decrease the risk of developing stomach ulcers in people who are at risk of developing stomach ulcers with NSAIDs.
What is the most important information I should know about Vimovo?Vimovo may increase the chance of a heart attack or stroke that can lead to death. This chance increases with longer use of NSAID medicines and in people who have heart disease.
Vimovo can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can happen without warning symptoms and may cause death. The chance of a person getting an ulcer or bleeding increases when taking medicines called steroid hormones (corticosteroids) and blood thinners (anticoagulants), longer use, smoking, drinking alcohol, older age, or if you have poor health.
Vimovo may cause high blood pressure or worsen high blood pressure. Your blood pressure will need to be monitored while you are taking Vimovo.
Vimovo may cause serious allergic reactions. Tell your doctor or get medical help right away if you develop sudden wheezing, swelling of your lips, tongue, throat, or body; rash, fainting, or problems breathing or swallowing.
Vimovo may cause serious skin reactions. Tell your doctor or get medical help right away if you develop reddening of your skin with blisters or peeling or if you develop blisters and bleeding of your lips, eyelids, mouth, nose, and genitals.
Vimovo may cause liver problems. Tell your doctor if you develop yellowing of the skin or the whites of your eyes, dark urine, or feel tired.
Vimovo, when taken for long periods of time, may cause kidney problems.
Vimovo may increase your risk of bone fractures. Talk to your doctor about your risk for fractures if you take Vimovo for a long period of time.
Who should not take Vimovo?Do not take Vimovo if you have had an asthma attack, hives, or other allergic reaction after taking aspirin or other NSAID medicine; if you are allergic to any of the ingredients in Vimovo; if you are allergic to any other PPI medicine; for pain right before or after heart bypass surgery; or if you are in the late stages of pregnancy (third trimester).
What should I tell my doctor before I take the first dose of Vimovo?Tell your doctor about all prescription, over-the-counter, and herbal medication you are taking before beginning treatment with Vimovo. Also, talk to your doctor about your complete medical history, especially if you have liver or kidney problems, high blood pressure, heart failure, a history of stomach or intestinal bleeding, a history of stomach or intestinal ulcers, ulcerative colitis or Crohn's disease (inflammatory diseases of the digestive system), are pregnant, plan to become pregnant, or are breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: The recommended dose is one tablet taken twice daily. Each tablet of Vimovo consists of either 375 milligrams (mg) of naproxen and 20 mg of esomeprazole or 500 mg of naproxen and 20 mg of esomeprazole.
How should I take Vimovo?Take Vimovo exactly as prescribed by your doctor. Do not change your dose or stop Vimovo without first talking to your doctor. Take Vimovo at least 30 minutes before a meal. Swallow the tablets whole with liquid. Do not split, chew, crush or dissolve the tablets.
Your doctor may tell you to take vitamin D and calcium supplements during treatment with Vimovo.
You may use antacids while taking Vimovo.
What should I avoid while taking Vimovo?Vimovo may cause you to become drowsy or less alert. Avoid driving, operating dangerous machinery, or participating in any hazardous activity until you know how Vimovo affects you.
You should not breastfeed if you are taking Vimovo.
What are possible food and drug interactions associated with Vimovo?If Vimovo is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Vimovo with the following: ACE inhibitors, alcohol, anticoagulants (such as warfarin), antiplatelet medications (such as aspirin and other NSAIDs), atazanavir, beta-blockers (such as propranolol), cholestyramine, cilostazol, corticosteroids, diazepam, digoxin, diuretics (water pills), hydantoins, iron salts, ketoconazole, lithium, methotrexate, nelfinavir, probenecid, saquinavir, SSRIs, sulfonamides, sulfonylureas, or voriconazole.
What are the possible side effects of Vimovo?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: stomach inflammation, indigestion, diarrhea, stomach ulcers, upper stomach pain, nausea
Can I receive Vimovo if I am pregnant or breastfeeding?Do not take Vimovo if you are in the late stages of pregnancy (third trimester). Tell your doctor immediately if you are pregnant or plan to become pregnant.
You should not breastfeed while taking Vimovo, since it can pass into breast milk and may harm your baby.
What should I do if I miss a dose of Vimovo?Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Take the next dose at your regularly scheduled time. Do not take two doses at once.
How should I store Vimovo?Store at room temperature. Keep Vimovo in the original bottle, tightly closed.
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