Generic Name: Esomeprazole

  • What is this medication and its most common uses?

    Vimovo is a combination medicine that contains naproxen (a nonsteroidal anti-inflammatory drug [NSAID]) and esomeprazole (a medicine that helps to reduce the acid in your stomach). Vimovo is used to relieve the signs and symptoms of rheumatoid arthritis (a type of arthritis that involves inflammation of the joints); osteoarthritis (a type of arthritis that involves the breakdown of cartilage in the joints) and ankylosing spondylitis (arthritis of the spine). Vimovo also decreases the risk of developing ulcers of the stomach in people who are at risk for NSAID-associated stomach ulcers.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Naproxen works by reducing pain and inflammation associated with osteoarthritis and rheumatoid arthritis. Esomeprazole works by reducing the amount of acid in your stomach, thereby decreasing the risk of developing stomach ulcers that can be caused by taking naproxen.

    What are the beneficial effects of this medication and when should I begin to have results?


    Osteoarthritis: Vimovo can help reduce joint pain or tenderness and increase movement and your ability to perform your daily activities.

    Rheumatoid Arthritis: Vimovo can help reduce joint swelling, duration of morning stiffness, and increase movement.

    Ankylosing Spondylitis: Vimovo can help reduce night pain, morning stiffness, and pain at rest.

    Reduced Risk of Stomach Ulcers: Studies have shown that treatment with Vimovo reduced the risk of developing stomach ulcers compared with people who took naproxen alone.

    When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Vimovo exactly as your healthcare provider has prescribed.

    How do I know it is working?

    You may start to notice an improvement in your symptoms. This is a good indicator that your medication is working. Your healthcare provider will ask you questions from time to time to check improvement of your condition.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Like all medications that contain NSAIDs, Vimovo may increase the chance of a heart attack or stroke that can lead to death. This chance increases with longer use of NSAID medicines, in people who have heart disease. NSAID-containing medications, such as Vimovo, should never be used before or after a type of heart surgery called coronary artery bypass graft (CABG). As with all medications that contain NSAIDs, Vimovo may increase the chance of stomach and intestinal problems, such as bleeding or an ulcer, which can occur without warning and may cause death. Elderly patients are at greater risk for serious gastrointestinal events.

    More common side effects may include: upset stomach, inflammation of your stomach, diarrhea, stomach ulcer, upper stomach pain, nausea.

    Less common side effects may include:

    High blood pressure, heart failure, or worsening of existing high blood pressure.

    Fluid retention with symptoms such as swelling of your body, hands, or feet, or sudden weight gain or trouble breathing.

    Kidney injury, if you use it for a long period. Your risk can increase if you have kidney problems; heart failure; liver problems; are taking certain medications, including diuretics (water pills) (such as furosemide or hydrochlorothiazide) or blood/heart medications known as angiotensin-converting enzyme (ACE) inhibitors (such as enalapril or lisinopril); or are elderly.

    Liver injury with symptoms such as nausea, tiredness, weakness, itching, pain in right upper area of your stomach, or yellowing of your skin or the whites of your eyes.

    Serious allergic reaction with symptoms such as rash, hives, or swelling of your face, lips, tongue, or throat, which may cause difficulty breathing or swallowing.

    Diarrhea that does not go away.

    Fractures of the hip, wrist, or spine, if you take multiple doses a day for long periods.

    Low blood magnesium levels with symptoms such as seizures, dizziness, abnormal or fast heartbeat, jitteriness, jerking movements or shaking, muscle weakness, spasms of your hands and feet, cramps or muscle aches, or spasm of your voice box.

  • Who should not take this medication?

    Do not take Vimovo if you are allergic to it, any of its ingredients, or to any medicine known as a proton pump inhibitor (PPI).

    Do not take Vimovo if you have experienced asthma, hives, or allergic-type reactions after taking aspirin or other NSAIDs (such as ibuprofen).

    Do not take Vimovo in the late stage of your pregnancy.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Vimovo. Also, talk to your healthcare provider about your complete medical history, especially if you have allergies, low magnesium levels; liver, kidney, stomach, or heart problems; history of asthma; high blood pressure; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: The recommended dose is one tablet twice a day.

  • How should I take this medication?

    Take Vimovo exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Vimovo without first talking to your healthcare provider.

    Take Vimovo at least 30 minutes before a meal. Swallow the tablets whole with liquid. Do not split, chew, crush, or dissolve the tablets.

    Your healthcare provider may tell you to take vitamin D and calcium supplements during treatment with Vimovo.

    You may use antacids while you are taking Vimovo.

  • What should I avoid while taking this medication?

    Do not take Vimovo with another medication called Aleve, or other medications that contain naproxen, since all these medicines contain the same active ingredient.

    Do not drive or operate machinery until you know how Vimovo affects you.

  • What are the possible food and drug interactions associated with this medication?

    If Vimovo is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Vimovo may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

  • May I receive this medication if I am pregnant or breastfeeding?

    Do not take Vimovo if you are in the late stage of your pregnancy or if you are breastfeeding. Vimovo can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Vimovo, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature. Protect from moisture.

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