Xalkori

Generic Name: Crizotinib

  • What is Xalkori?

    Xalkori is a medicine used to treat non-small cell lung cancer, a type of lung cancer caused by a defect in a specific gene, that is locally advanced or has spread to other parts of the body.

  • What is the most important information I should know about Xalkori?

    Xalkori can cause life-threatening swelling (inflammation) of the lungs (pneumonitis) during treatment. Symptoms may be similar to those symptoms from lung cancer. Tell your doctor immediately if you have any new or worsening symptoms, including trouble breathing or shortness of breath, cough with or without mucous, or fever.

    Xalkori can cause liver problems, therefore you should tell your doctor right away if your skin or the whites of your eyes turn yellow, you feel tired, your urine turns dark or brown (tea color), you have nausea or vomiting, decreased appetite, pain on the right side of your stomach, or if you easily bruise or bleed more than normal. Your doctor will perform liver tests while you are taking Xalkori.

    Xalkori can harm your unborn baby. Women who are able to become pregnant and men who take Xalkori should use birth control during treatment and for 3 months after stopping Xalkori.

    Tell your doctor immediately if you have any changes in vision, such as flashes of light, blurred vision, light hurting your eyes, or increased floaters.

  • Who should not take Xalkori?

    Your doctor will determine if you should not receive Xalkori prior to its administration. Do not take Xalkori if you are allergic to it or any of its ingredients.

  • What should I tell my doctor before I take the first dose of Xalkori?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Xalkori. Also, talk to your doctor about your complete medical history, especially if you are pregnant, plan to become pregnant, or are breastfeeding; have liver or kidney problems; or have heart problems, including a condition called long QT syndrome (very fast or abnormal heart beats).

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended dose is 250 milligrams (mg) twice a day. Your doctor may adjust your dose depending on how you respond to Xalkori.

  • How should I take Xalkori?

    Take Xalkori exactly as prescribed by your doctor. Do not change your dose or stop taking Xalkori unless your doctor tells you to. Do not crush, dissolve, or open Xalkori capsules. Swallow Xalkori capsules whole, with or without food.

  • What should I avoid while taking Xalkori?

    You should avoid becoming pregnant while you are taking this medication.

    Do not drink grapefruit juice or eat grapefruit during your treatment with Xalkori. It may make the amount of Xalkori in your blood increase to a harmful level.

    Xalkori can cause changes in your vision, dizziness, and tiredness. If you have any of these symptoms, use caution when driving a car, using machinery, or doing anything that needs you to be alert.

  • What are possible food and drug interactions associated with Xalkori?

    If Xalkori is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is important to check with your doctor before combining Xalkori with any other medication.

  • What are the possible side effects of Xalkori?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: constipation, diarrhea, nausea, swelling of your hands and feet, vomiting

  • Can I receive Xalkori if I am pregnant or breastfeeding?

    Xalkori can harm your unborn baby if taken during pregnancy. You should avoid becoming pregnant while taking this medication. The effects of Xalkori during breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Xalkori?

    If you miss a dose of Xalkori, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Xalkori?

    Store at room temperature. Keep Xalkori in its original container and do not touch or handle crushed or broken Xalkori capsules.