What is Xarelto?Xarelto is a medicine used to reduce your risk of stroke and blood clots if you have a medical condition called atrial fibrillation (an irregular, fast heartbeat). Xarelto is also used to reduce your risk of forming a blood clot in your legs and lungs if you have just had a hip or knee replacement surgery.
What is the most important information I should know about Xarelto?If you have atrial fibrillation and are taking Xarelto, do not stop taking it without first talking to your doctor. Stopping Xarelto can increase your risk of having a stroke. If you have to stop taking Xarelto, your doctor may prescribe another blood thinner medicine to prevent a blood clot from forming.
Xarelto can cause bleeding which can be serious. While you are taking Xarelto, you are likely to bruise more easily and it may take longer for bleeding to stop.
Call your doctor or get medical help immediately if you develop unexpected bleeding or bleeding that lasts a long time; bleeding that is severe or you cannot control; red, pink, or brown urine; bright red or black stools; if you cough up blood or blood clots; if you vomit blood or your vomit looks like "coffee grounds;" if you develop headaches, feel dizzy, or weak; or if you experience pain, swelling, or new drainage at wound sites.
Tell all your doctors and dentists that you are taking Xarelto. They should talk to the doctor who prescribed Xarelto for you before you have any surgery, medical, or dental procedure.
Who should not take Xarelto?Do not take Xarelto if you currently have certain types of abnormal bleeding. Talk to your doctor before taking Xarelto if you currently have unusual bleeding.
Do not take Xarelto if you are allergic to it or any of its ingredients.
What should I tell my doctor before I take the first dose of Xarelto?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Xarelto. Also, talk to your doctor about your complete medical history, especially if you have ever had bleeding problems, have liver or kidneys problems, are pregnant, plan to become pregnant, if you are breastfeeding, or plan to breastfeed.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: The recommended dose is 20 milligrams (mg) taken once a day. If you have kidney impairment, your doctor will adjust your dose appropriately.
Hip or Knee Replacement Surgery
Adults: The recommended dose is 10 mg taken once a day.
If you are receiving any other blood thinner, your doctor will instruct you on how to start taking Xarelto.
How should I take Xarelto?Take Xarelto exactly as prescribed by your doctor.
Atrial Fibrillation: Take Xarelto once a day with your evening meal.
Hip or Knee Replacement Surgery: Take Xarelto once a day with or without food.
What should I avoid while taking Xarelto?Do not change your dose or stop taking Xarelto unless your doctor tells you to.
What are possible food and drug interactions associated with Xarelto?If Xarelto is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Xarelto with the following: aspirin, blood thinners (such as enoxaparin, heparin, or warfarin), carbamazepine, clarithromycin, clopidogrel, conivaptan, erythromycin, medicines to treat fungal infections (such as fluconazole, itraconazole, or ketoconazole), indinavir, lopinavir, nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen or naproxen), ritonavir, phenytoin, prasugrel, rifampin, St. John's wort, or ticagrelor.
What are the possible side effects of Xarelto?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: bleeding
Can I receive Xarelto if I am pregnant or breastfeeding?The effects of Xarelto during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Xarelto?If you miss a dose of Xarelto, take it as soon as you remember on the same day, and return to your regular dosing schedule on the following day. Do not apply two doses at once.
How should I store Xarelto?Store at room temperature.